2015 57th ASH Annual Meeting - účast ČR

101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Poster III

Major Route Additional Chromosomal Aberrations (ACA) Precede Increase of Blasts in CML: An Analysis of the German CML-Studies III and IIIA

Autoři: Dr. Christian Dietz, Ph.D.; MD Alice Charlotte Fabarius, Ph.D.; Michael Lauseker; MD Susanne Saussele; Lida Kalmanti; MD Sébastien Rinaldetti; MD Claudia Haferlach; Prof. MD Brigitte M. Schlegelberger; Martine Jotterand; Alois Gratwohl; Prof. Dr. Axel R. Zander; MD Nicolaus Kröger; M.D. Dietrich W. Beelen; MD Jürgen Novotny, Ph.D.; Prof. Christoph Nerl; Prof. MD Christof Scheid, Ph.D.; Prof. Dr. Karsten Spiekermann; prof. MUDr. Jiří Mayer, CSc.; Dr. Herbert G. Sayer, Ph.D.; Christiane Falge; MD Donald W. Bunjes, PhD; Prof. Dr. med. Hartmut Döhner (Doehner); Prof. Dr. med. Arnold Ganser; Prof. Dr. Peter Brossart; M.D. Rainer Schwerdtfeger; Herrad Baumann; Prof. Dr. Rolf Kuse; MD Hans Walter Lindemann; MD Matthias Bormann; Prof. Dr. Bernd Hertenstein; MD Gabriela M. Baerlocher; Prof. Dr. Carlo Aul; MD Peter Staib; MD Matthias Edinger; Michael Schatz; Prof. Dr. med. Dr. rer nat. Axel A. Fauser; Prof. Dr. Renate Arnold, PhD; Prof. Dr. Dieter K. Hossfeld; Prof. Dr. Hans-Jochem Kolb; Prof. Dr. Susanne Schnittger, PhD; Prof. Dr. med. Martin C. Müller; Prof. Dr. Andreas Reiter, M.D.; MD Andreas Hochhaus; Dr. rer. biol. hum. Markus Pfirrmann, M.Sc.; MD Joerg Hasford; MD Michele Baccarani; Prof. Dr. Rüdiger Hehlmann
Číslo abstraktu: 1581
Kategorie: Maligní lymfomy a leukémie

Polycythemia of Mice with Human Gain-of-Function EPOR (mtHEPOR) Is Transiently Corrected in Perinatal Life in Association with Low Epo and Increased Erythrocyte Phosphatidylserine Exposure

Autoři: Jihyun Song, MS; Mgr. Barbora Kráľová; Mgr. Monika Horváthová, Ph.D.; Donghoon Yoon; MD Josef T. Prchal; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 3335
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Analysis of Minimal Residual Disease in Follicular Lymphoma Patients in Gadolin, a Phase III Study of Obinutuzumab Plus Bendamustine Versus Bendamustine in Relapsed/Refractory Indolent Non-Hodgkin Lymphoma

Autoři: Dr. Christianne Pott, PhD; MUDr. David Belada, Ph.D.; Nathalie Danesi, Ph.D.; Guenter Fingerle-Rowson; M.D. John G. Gribben, DSC, FMedSci; MPhil Chris Harbron; Eva Hoster; Dr. Brad S. Kahl, Ph.D.; Kirsten E. Mundt, Ph.D.; MD Catherine Sebban; Laurie H. Sehn; MD Bruce D. Cheson, BA
Číslo abstraktu: 3978
Kategorie: Maligní lymfomy a leukémie

102. Regulation of Iron Metabolism: Poster III

Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model

Autoři: RNDr. Leona Rašková-Kafková, Ph.D.; MVDr. Zuzana Somíková; Mgr. Jana Kučerová; Mgr. Lenka Calábková; Mgr. Pavla Lužná; Mgr. Ján Štetka; Mgr. Dana Šimková; MvDr. Dalibor Doležal; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 3351
Kategorie: Mnohočetný myelom

112. Thalassemia and Globin Gene Regulation: Poster III

Sickle Cell Anemia in a Child with Three β-Globin Clusters (β-S/β-S, β-A): Loss of LCR and 3' HS1 in the Duplicated Wild-Type β-Globin Cluster Does Not Fully Abrogate Its Transcript

Autoři: N. Scott Reading, Ph.D.; Dr. Barnaby E. Clark, Ph.D.; Jihyun Song, MS; Claire C Shooter; MD Robin E. Miller; Dr. Archana M. Agarwal, MBBS; MD Swee Lay Thein; Doc.RNDr. Vladimír Divoký, Ph.D.; MD Josef T. Prchal
Číslo abstraktu: 3371
Kategorie: Maligní lymfomy a leukémie

Pathophysiology and Treatment of Beta-Thalassemia: Investigations of Heme Oxygenase 1 and Its Inhibitors

Autoři: Daniel Garcia Santos, Ph.D.; Mgr. Zuzana Židová; Marc Mikhael, PhD; Amel Hamdi, Ph.D.; Mgr. Monika Horváthová, Ph.D.; M.D. Prem Ponka, Ph.D.
Číslo abstraktu: 3373
Kategorie: Maligní lymfomy a leukémie

508. Bone Marrow Failure: Attack on the Clones – Hematopoietic Stem/Progenitor Cell Defects

Somatic Genetic and Epigenetic Architecture of Myelodysplastic Syndromes Arising from GATA2 Deficiency

Autoři: Victor Bengt Pastor Loyola, MSc.; MD Shinsuke Hirabayashi; Sandra Pohl, Ph.D.; Emilia J. Kozyra; Albert Catala; MD Barbara De Moerloose; Prof. MD Michael Dworzak; Prof. MD Henrik Hasle; Riccardo Masetti; MD Markus Schmugge (Schmugge-Liner); Owen Smith; prof. MUDr. Jan Starý, DrSc.; Marek Ussowicz; MD Marry M. van den Heuvel-Eibrink, PhD; MUDr. Ester Mejstříková, Ph.D.; MD Ulrich Salzer; Prof. Dr. Michael Luebbert (Lübbert), Ph.D.; MD Daniel Heudobler; MD David Betts; MD Jose Cervera; MD Gudrun Göhring; Prof. Dr. Oskar A. Haas; MD Olga Haus; prof. Ing. Kyra Michalová, DrSc.; MD Francesco Pasquali, Ph.D.; Dr. Joelle Tchinda; MD Nadine van Roy; Prof. MD Brigitte M. Schlegelberger; H.Berna Beverloo, PhD; Peter Noellke; Ayami Yoshimi-Nöllke ; Prof. MD Franco Locatelli, PhD; MD Brigitte Strahm; M.D. Jaroslaw P. Maciejewski, Ph.D., FACP; Michael Rehli, Ph.D.; Prof. MD Charlotte M. Niemeyer, PhD; MD Marcin W. Wlodarski
Číslo abstraktu: 299
Kategorie: Maligní lymfomy a leukémie

508. Bone Marrow Failure: Poster I

Use of Human Pluripotent Stem Cells to Model the Hematopoietic Defect and Repair of Human Telomerase Deficiency

Autoři: MD George Scaria, Ph.D.; Trevor Argall, BS; Shyam S. Jose; Laura Bendzick, BS; MD Dan S. Kaufman, Ph.D.
Číslo abstraktu: 1212
Kategorie: Maligní lymfomy a leukémie

603. Oncogenes and Tumor Suppressors: Poster I

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Autoři: Kathrin Krowiorz; Razan Jammal; Stephan Emmrich; Arefeh Rouhi, Ph.D.; MD Michael Heuser; Dr. Lars Bullinger; Prof. Dr. Konstanze Döhner; Lai Courteney; Dr. Tobias Maetzig , Ph.D.; Vera Martins; Medhanie Assmelash Mulaw, BSc, MSc, PhD; Dr.rer.nat Dirk Heckl, Ph.D.; MD Christian Michel Zwaan, PhD; prof. MUDr. Jan Starý, DrSc.; MD Andre Baruchel, PhD; MD Valerie de Haas, Ph.D.; MD Dirk Reinhardt, PhD; Maarten W.J. Fornerod, Ph.D.; Prof. Dr. med. Hartmut Döhner (Doehner); Dr. Jens Ruschmann, Ph.D.; MD Marry M. van den Heuvel-Eibrink, PhD; MD R. Keith Humphries, Ph.D.; MD Florian Kuchenbauer, Ph.D.; MD Jan-Henning Klusmann
Číslo abstraktu: 1244
Kategorie: Nádory dětského a adolescentního věku

Patients with Chronic Myeloid Leukemia Show Different Modulation of MYB-Dependent Oncogenic Pathway in the Course of Hematopoietic Differentiation upon Sensitivity to the TKI Treatment

Autoři: Bc. Klára Šrůtová; Mgr. Nikola Čuřík, Ph.D.; RNDr. Jitka Koblihová, Ph.D.; Bc. Filipp Savvulidi; MUDr. Hana Klamová, CSc.; Prof. Dr. Danilo Perrotti, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.; Mgr. Kateřina Machová (Poláková), Ph.D.
Číslo abstraktu: https://as
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

604. Molecular Pharmacology and Drug Resistance in Myeloid Diseases: Poster II

SNPs in the Promoter of the Gene Encoding Transmembrane Transporter SLC22A4 (hOCTN1) Are Significantly Associated with an Alteration of Gene Expression and with Resistance to the Imatinib Treatment in Chronic Myeloid Leukemia

Autoři: MUDr. Monika Jarušková; Rajna Hercog; Mgr. Nikola Čuřík, Ph.D.; Vladimir Benes; MUDr. Hana Klamová, CSc.; Mgr. Kateřina Machová (Poláková), Ph.D.
Číslo abstraktu: 2463
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

605. Molecular Pharmacology, Drug Resistance – Lymphoid and Other Diseases: Novel Targets and Therapeutics

Subgroups of T-Cell Prolymphocytic Leukemia (T-PLL) Discovered By High-Throughput Ex Vivo Drug Testing and Genetic Profiling

Autoři: Emma I. Andersson, MSc.; MD Shady Adnan, MSc.; MD Leopold Sellner; Dorine Bellanger; Alexandra Schrader; Giuliano Crispatzu; MD Henan Zhang; MD Carlos Cuesta-Mateos, PhD; prof. MUDr. Edgar Faber, CSc.; MD Steffen Koschmieder; MD Tim H. Brummendorf, PhD; Krister Wennerberg, Ph.D.; MD Wei Ding, Ph.D.; MD Marc-Henri Stern, Ph.D.; MD Marco Herling; Simon Anders, Ph.D.; Wolfgang Huber, PhD; Prof. Dr. med. Thorsten Zenz; MD Satu Mustjoki, PhD
Číslo abstraktu: 315
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

605. Molecular Pharmacology, Drug Resistance – Lymphoid and Other Diseases: Poster I

L-Asparaginase More Effectively Targets Leukemic Cells with Low Glycolytic Activity

Autoři: Bc. Markéta Šimčíková; Alena Pecinová; Mgr. Ivana Heřmanová; David Pajuelo Reguera; Bc. Kateřina Rejlová; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Mgr. Jan Stuchlý; RNDr. Tomáš Mráček, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Mgr. Júlia Starková, Ph.D.
Číslo abstraktu: 1285
Kategorie: Maligní lymfomy a leukémie

612. Acute Lymphoblastic Leukemia: Clinical Studies I

Characterization of Leukemias with ETV6-ABL1 Fusion

Autoři: MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Anthony V. Moorman, PhD; Giovanni (Gianni) Cazzaniga, PhD; MD Martin Stanulla, MSc; Richard C. Harvey, Ph.D.; MD Catherine Roberts; Dr. Sue L. Heatley; Prof. Dr. Mignon L. Loh; MD Marina Konopleva, Ph.D.; I-Ming L. Chen, D.V.M., M.S.; MUDr. Olga Zimmermannová; BSc Claire Schwab; Owen Smith; MD Marie-Joelle Mozziconacci; Prof. Dr. Christian Chabannon; Dr. Myungshin Kim; MD J.H. Frederik Falkenburg, Ph.D.; Dr. Alice Norton; Karen Marshall; Prof. Dr. Oskar A. Haas; Mgr. Júlia Starková, Ph.D.; Mgr. Jan Stuchlý; MD Stephen P. Hunger; Prof. Deborah White; MD Charles G. Mullighan, MBBS, MSc; Prof. Dr. Cheryl L. Willman; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 84
Kategorie: Maligní lymfomy a leukémie

612. Acute Lymphoblastic Leukemia: Clinical Studies Poster II

Clinical Relevance of Low Burden BCR-ABL1 Mutations Detectable By Amplicon Deep Sequencing (DS) in Philadelphia-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients (pts): The Type of Mutation Matters

Autoři: Simona Soverini; Caterina De Benedittis; Claudia Venturi; M.D. Cristina Papayannidis; Manuela Mancini; Mgr. Kateřina Machová (Poláková), Ph.D.; Prof. Domenico Russo; Paola Bresciani; MD Alessandra Iurlo; MD Elisabetta Abruzzese; MD Federica Sorà; MD Michele Baccarani; MD Michele Cavo; MD Torsten Haferlach; Prof.MD Giovanni Martinelli
Číslo abstraktu: 2489
Kategorie: Maligní lymfomy a leukémie

612. Acute Lymphoblastic Leukemia: Clinical Studies Poster III

MRD Monitoring Using Minor-BCR-ABL1 Genomic Breakpoint in Childhood ALL Identifies a Subgroup with Distinct Biology and a Very Poor Prognosis

Autoři: Mgr. Lenka Hovorková; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Nicola C. Venn, PhD; Walter Muskovic; Jodie E. Giles; Mgr. Jana Linhartová, Ph.D.; Mgr. Kateřina Machová (Poláková), Ph.D.; MBBS Peter J. Shaw, FRACP,MA,MRCP; Rosemary Sutton, PhD; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 3727
Kategorie: Maligní lymfomy a leukémie

612. Acute Lymphoblastic Leukemia: Clinical Studies: Special Aspects of Childhood ALL

Acute Leukemias of Ambiguous Lineage; Study on 247 Pediatric Patients

Autoři: Prof. MUDr. Ondřej Hrušák, Ph.D.; Aleš Lukš; Mgr. Iveta Janotová; MUDr. Ester Mejstříková, Ph.D.; Mgr. Martina Vášková; Dr. Kristen Bleckmann; Dr. Benigna Konatkowska; Julie Irving; MUDr. Kamila Polgárová; MD Hiroto Inaba, Ph.D.; Kjeld Schmiegelow; Jorge Gabriel Rossi, Ph.D.; MD Maria Sara Felice, Ph.D.; MD Luciano Dalla-Pozza; Jessa Morales; Mary Sartor, Ph.D.; Prof. MD Michael Dworzak; MD Anja Möricke; Myriam Campbell; MD Maria Elena Cabrera; Neda Marinov; MD Sarah Elitzur; MD Shai Izraeli; MD Valerie de Haas, Ph.D.; MUDr. Alexandra Kolenová, Ph.D.; MUDr. Peter Švec, Ph.D.; Elena Kreminska; Simone Stokley, FRCPath; MD Sophia Polychronopoulou, Ph.D.; Elaine da Costa; MD Hanne Vibeke Marquart, Ph.D.; MD Antonis Kattamis; MD Richard Ratei; MD Dirk Reinhardt, PhD; Kathy Jackson; Anthony V. Moorman, PhD; MD Martin Schrappe; prof. MUDr. Jan Starý, DrSc.
Číslo abstraktu: 252
Kategorie: Maligní lymfomy a leukémie

613. Acute Myeloid Leukemia: Clinical Studies: Poster III

Exchange Transfusion and Leukapheresis in Pediatric AML Patients with High Risk of Early Death for Bleeding and Leukostasis

Autoři: MD Ursula Creutzig, PhD; M.D. Claudia Rossig; Prof. MD Michael Dworzak; MD Arend von Stackelberg; Wilhelm Woessmann; prof. MUDr. Jan Starý, DrSc.; Martin Zimmermann, Ph.D.; MD Dirk Reinhardt, PhD
Číslo abstraktu: 3741
Kategorie: Maligní lymfomy a leukémie

615. Acute Myeloid Leukemia: Commercially available Therapy, excluding Transplantation: Poster I

Decitabine Improves Response Rate and Prolongs Progression Free Survival in Older Patients with Newly Diagnosed Acute Myeloid Leukemia with Monosomal Karyotype: A Subgroup Analysis of the Daco-16 Trial

Autoři: MD Agnieszka Wierzbowska, PhD; Ewa Wawrzyniak, Ph.D.; Prof. Dr. Agnieszka Pluta; MD Tadeusz Robak, PhD.; MD Grzegorz Mazur, PhD; Anna Dmoszynska; prof. MUDr. Jaroslav Čermák, CSc.; M.D. Albert Oriol; MD Farhad Ravandi Ravandi; M.D. Hagop M. Kantarjian
Číslo abstraktu: 1336
Kategorie: Maligní lymfomy a leukémie

617. Acute Myeloid Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Molecular Markers and Clinical Implication

Landscape of Secondary Genetic Lesions in Acute Myeloid Leukemia with Inv(16)/CBFB-MYH11

Autoři: Annette Fasan, PhD; MD Claudia Haferlach; Karolina Perglerová; Sonja Schindela; Prof. Dr. Susanne Schnittger, PhD; M.D. Wolfgang Kern; MD Torsten Haferlach
Číslo abstraktu: 801
Kategorie: Maligní lymfomy a leukémie

617. Acute Myeloid Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster

Abnormalities Detected By Array CGH and Fluorescence in Situ Hybridization in AML with Normal Karyotype Lacking Mutations in NPM1, CEBPA, RUNX1 and MLL Partial Tandem Duplications Are Associated with Unfavorable Outcome

Autoři: MD Claudia Haferlach; Kathleen Zieschang; Prof. Dr. Susanne Schnittger, PhD; Tamara Alpermann; Melanie Zenger; Karolina Perglerová; M.D. Wolfgang Kern; MD Torsten Haferlach
Číslo abstraktu: 1371
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

BAALC Expression Is a Feasible Marker for Risk Stratification and Detection of Minimal Residual Disease in Cytogenetically Normal Acute Myeloid Leukemia

Autoři: Simone Weber; Tamara Alpermann; Karolina Perglerová; Prof. Dr. Susanne Schnittger, PhD; MD Torsten Haferlach; MD Claudia Haferlach; M.D. Wolfgang Kern
Číslo abstraktu: 1373
Kategorie: Maligní lymfomy a leukémie

Immune Response in Acute Myeloid Leukemia with Mutated Nucleophosmin

Autoři: Kateřina Kuželová, Ph.D.; Mgr. Barbora Brodská, Ph.D.; Ing. Jana Marková; MD Grzegorz Helbig, Ph.D.; Prof. Dr. Slawomira Kyrcz-Krzemien, Ph.D.; prof. MUDr. Petr Cetkovský, Ph.D.
Číslo abstraktu: 2572
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

AML with RUNX1 Mutations and Loss of RUNX1 Wild-Type - a Distinct Subset?

Autoři: MD Claudia Haferlach; Niroshan Nadarajah, MSc; Annette Fasan, PhD; Karolina Perglerová; M.D. Wolfgang Kern; Prof. Dr. Susanne Schnittger, PhD; MD Torsten Haferlach
Číslo abstraktu: 2578
Kategorie: Maligní lymfomy a leukémie

Prognostic Relevance of Recurrent Genetic Aberrations in Pediatric Acute Megakaryoblastic Leukemia

Autoři: MD Jasmijn D.E. de Rooij; Riccardo Masetti; MD Marry M. van den Heuvel-Eibrink, PhD; Jean-Michel Cayuela, PhD.; Prof.MUDr. Jan Trka, Ph.D.; MD Dirk Reinhardt, PhD; Edwin Sonneveld, PhD; Prof. Todd Allen Alonzo, PhD; Maarten W.J. Fornerod, Ph.D.; Martin Zimmermann, Ph.D.; Martina Pigazzi, Ph.D.; Prof. MD Rob Pieters, PhD; MD Soheil Meshinchi, PhD; MD Christian Michel Zwaan, PhD; Prof. MD Franco Locatelli, PhD
Číslo abstraktu: 2598
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Retrospective Analysis of Minimal Residual Disease-Guided Preemptive Treatment in Patients with AML and MDS - the SAL Study Group Experience

Autoři: MD Ekaterina Bulycheva; prof. MUDr. Jiří Mayer, CSc.; MD William Hermann Krüger, Ph.D.; Prof. Dr.med. Peter Dreger; Anna Mies; MUDr. Zuzana Šustková; Prof. MUDr. Zdeněk Ráčil, Ph.D.; Mgr. Jiřina Procházková, Ph.D.; MD Eva Walter; Carsten Hirt; MD Mark Ringhoffer; MD Wolfgang E. Berdel; Prof. MD Hubert Serve; MD Christoph Röllig; MD Katja Sockel; Prof. Dr. Martin Bornhaeuser (Bornhäuser); MD Gerhard Ehninger; M.D. Christian Thiede; MD Uwe Platzbecker
Číslo abstraktu: 3817
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Does Age of Patients Influence the Composition of Gene Mutations in Myeloid Neoplasms?

Autoři: Manja Meggendorfer, PhD; M.D. Wolfgang Kern; Karolina Perglerová; Prof. Dr. Susanne Schnittger, PhD; MD Claudia Haferlach; MD Torsten Haferlach
Číslo abstraktu: 3821
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Molecular Characterization of Philadelphia Chromosome Positive Acute Myeloid Leukemia - New Provisional Entity?

Autoři: Simone Weber; Manja Meggendorfer, PhD; Niroshan Nadarajah, MSc; Karolina Perglerová; Prof. Dr. Susanne Schnittger, PhD; MD Claudia Haferlach; M.D. Wolfgang Kern; MD Torsten Haferlach
Číslo abstraktu: 3846
Kategorie: Maligní lymfomy a leukémie

Higher Percentages of Ring Sideroblasts and SF3B1 Mutations in Patients with AML Correlate with Mutations in TP53 and Adverse Cytogenetics, but Have No Independent Impact on Outcome

Autoři: MD Pedro Martin-Cabrera; Sabine Jeromin, Ph.D.; Tamara Alpermann; Karolina Perglerová; MD Claudia Haferlach; M.D. Wolfgang Kern; MD Torsten Haferlach
Číslo abstraktu: 3847
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster

Rapid Identification of BCR/ABL1-like Acute Lymphoblastic Leukemia (ALL) Cases By Quantitative Real Time-PCR (Q-RT-PCR). Generation and Validation of a Predictive Statistical Modell

Autoři: MD Sabina Chiaretti, PhD; Sara Grammatico; Dr. Alfonso Piciocchi; Monica Messina; Anna Lucia Fedullo; Valentina Gianfelici; Grazia Fazio, Ph.D.; Nadia Peragine; Maria Paola Martelli; Paola Fazi; Dr. Marco Vignetti; MD Antonella Vitale; MUDr. Mgr. Cyril Šálek, Ph.D.; Giovanni (Gianni) Cazzaniga, PhD; Anna Guarini, Ph.D.; Robert (Robin) Foa (Foà)
Číslo abstraktu: 1410
Kategorie: Maligní lymfomy a leukémie

Library Preparation Is the Major Factor Affecting Differences in Results of Immunoglobulin Gene Rearrangements Detection on Two Major Next-Generation Sequencing Platforms

Autoři: MUDr. Michaela Kotrová; Henrik Knecht; Dr. Jack Bartram; Mgr. Vojtěch Bystrý; Giovanni (Gianni) Cazzaniga, PhD; Grazia Fazio, Ph.D.; Simone Ferrero; Elisa Genuardi; Dr. Ramón García Sanz; Andrea Grioni; Dr. Jeremy Hancock, Ph.D.; Cristina Jiminez (Jimenez); Dr. Marco Ladetto; Dr. John Moppett; Simona Songia; Dietrich Herrmann; Dr. Christianne Pott, PhD; Dr. Anton W. (Ton) Langerak ; Dr. Nikos Darzentas, PhD; Prof.MUDr. Jan Trka, Ph.D.; MUDr. Eva Froňková, Ph.D.; MD Monika Brüggemann (Bruegemann), PhD
Číslo abstraktu: 1411
Kategorie: Maligní lymfomy a leukémie

Validation of MRD Quantification By Flow Cytometry for Pediatric BCP ALL Relapsed Patients Treated on the Intreall Protocol

Autoři: MUDr. Ester Mejstříková, Ph.D.; Julie Irving; Dr. Leonid Karawajew, p; Marian Case; Jenny Jesson; Prof. Vaskar Saha, PhD, FRCP, FRCPath; Dr. Nicholas Goulden; Dr. Jeremy Hancock, Ph.D.; MD Arend von Stackelberg; Dr. Sarah Lawson; Prof. MD Michael Dworzak; MD Renate Panzer-Grümayer; MD Barbara Buldini; Lisa Eyre; MD Giuseppe Basso; Maddalena Paganin, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Mgr. Daniela Kužílková; prof. MUDr. Jan Starý, DrSc.; Doc. MUDr. Lucie Šrámková, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.; Dr. Cornelia Eckert, PhD
Číslo abstraktu: 1414
Kategorie: Maligní lymfomy a leukémie

Clustering Adult ACUTE Lymphoblastic Leukemia (ALL) Philadelphia Negative (Ph-) By Whole Exome Sequencing (WES) Analysis

Autoři: Anna Ferrari; Andrea Ghelli Luserna Di Rora; Italo Do Valle; Marianna Garonzi; Valentina Robustelli; MD Jesus Maria Hernandez Rivas, PhD; Dr. Alessandra Santoro; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Torsten Haferlach; Antonella Padella; Giorgia Simonetti, Ph.D.; M.D. Cristina Papayannidis; Maria Chiara Abbenante; Marco Sazzini; Alberto Ferrarini, Ph.D.; Julien Schira; Massimo Delledonne; Gastone Castellani; Daniel Remondini; Prof.MD Giovanni Martinelli
Číslo abstraktu: 2623
Kategorie: Maligní lymfomy a leukémie

622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Poster I

Unique Versus Common: Disease-Biased Immunoglobulin Gene Repertoires Along with Public Antigen Receptor Stereotypes in Marginal Zone B-Cell Lymphoproliferations

Autoři: Aliki Xochelli; Vasilis Bikos; Eleftheria Polychronidou; Andreas Agathangelidis; Frederic Charlotte; Panagiotis Moschonas; Zadie Davis; Monica Colombo; Maria Roumelioti; Lesley-Ann Sutton; Patricia Groenen; Myriam Boudjoghra; Patricia Algara; Alexandra Traverse-Glehen; Ana Ferrer; Evangelia Stalika; Maria Karypidou; George Kanellis; MD Christina Kalpadakis; MD Manuela Mollejo, Ph.D.; Prof. Dr. Gerasimos Pangalis; Panayiotis Vlamos; MD Rose-Marie Amini; prof. RNDr. Šárka Pospíšilová, Ph.D.; David Gonzalez, PhD; MD Maurilio Ponzoni; Dr. Achilles Anagnostopoulos; Veronique Giudicelli; Prof. Marie-Paule Lefranc; Blanca Espinet Sola; M.D. Panagiotis Panagiotidis; MD Miguel Angel Piris; Prof. Ming-Qing Du; Prof. MD Richard Rosenquist (Brandell), PhD; MD Theodora Papadaki, Ph.D.; MD Chrysoula Belessi; Manlio Ferrarini; Prof. David Graham Oscier; Dr. Dimitrios Tzovaras; M.D. Paolo Ghia, Ph.D.; MD Frederic Davi, PhD; Anastasia Hadzidimitriou; MD Kostas Stamatopoulos
Číslo abstraktu: 1479
Kategorie: Maligní lymfomy a leukémie

623. Lymphoma: Chemotherapy, excluding Pre-Clinical Models: Poster III

Primary Progressive Disease in Hodgkin Lymphoma Patients: A Retrospective Analysis from the German Hodgkin Study Group

Autoři: MD Stefanie Kreissl; Helen Goergen; MD Bastian von Tresckow; Dr. Karolin Behringer; Ing. Jana Marková; MD Andreas Lohri; Dr.med. Julia Meissner; Jose Zijlstra, MD; MD Richard Greil, Ph.D.; Prof. Dr. Max S Topp; M.D. Martin Soekler (Sökler); Prof. Dr. med. Hartmut Döhner (Doehner); MD Volker Diehl; Prof. MD Andreas Engert; MD Peter Borchmann, PhD
Číslo abstraktu: 3941
Kategorie: Maligní lymfomy a leukémie

624. Lymphoma: Therapy with Biologic Agents, excluding Pre-Clinical Models: Biologic Agents in B Cell Lymphoma

Ibrutinib Vs Temsirolimus: Results from a Phase 3, International, Randomized, Open-Label, Multicenter Study in Patients with Previously Treated Mantle Cell Lymphoma (MCL)

Autoři: prof. Simon A. Rule; Wojciech Jurczak; MD Mats Jerkeman, Ph.D.; Dr. Rodrigo Santucci Silva; MD Chiara Rusconi; Prof. MUDr. Marek Trněný, CSc.; MD Fritz C. Offner, PhD; MD Dolores Caballero; MD Cristina Joao, Ph.D.; MD Mathias Witzens-Harig; MD Georg Hess; Isabelle Bence-Bruckler; MD Seok-Goo Cho; Sriram Balasubramanian, Ph.D.; Nibedita Bandyopadhyay, Ph.D.; Steven Sun; MD Jenna Goldberg; John Bothos, Ph.D.; Christopher Enny; Shana Traina, Ph.D.; MD Aleksandra Rizo; MD Jessica Vermeulen, Ph.D.; MD Martin H. Dreyling, Ph.D.
Číslo abstraktu: 469
Kategorie: Maligní lymfomy a leukémie

624. Lymphoma: Therapy with Biologic Agents, excluding Pre-Clinical Models: Poster III

Prevalence and Prognostic Value of BCL2 and MYC Protein Expression within ABC and GCB Subtypes in Patients with Previously Untreated, Diffuse Large B-Cell Lymphoma: Analysis from the Phase III MAIN Study

Autoři: Elizabeth Punnoose; Franklin V. Peale Jr.; Guiyuan Lei, Ph.D.; Thomas Sandmann; Richard Bourgon; Edith Szafer-Glusman; An Do; Randy D. Gascoyne; MD Gilles Andre Salles, PhD; Prof. John Francis Seymour, MD, PhD, MBBS, FRACP; Prof. MUDr. Marek Trněný, CSc.; Laurie H. Sehn; F. Javier Munoz, PhD, MBA; Kirsten E. Mundt, Ph.D.
Číslo abstraktu: 3971
Kategorie: biologická cílená léčba

625. Lymphoma: Pre-Clinical – Chemotherapy and Biologic Agents: Immune Modulation and Microenvironment in Lymphoma

Lenalidomide Exhibits Activity in Mantle Cell Lymphoma through Increased NK Cell Mediated Cytotoxicity

Autoři: Patrick Hagner; Hsiling Chiu; Maria Ortiz-Estevez; Tsvetan Nikolov Biyukov; Carrie Brachman; Prof. MUDr. Marek Trněný, CSc.; Luca Arcaini; MD Franck Morschhauser, PhD; Antoine Thyss, Ph.D.; MD Stephan Stilgenbauer; MD Noel-Jean Milpied, Ph.D.; Reinhard Marks; MD Pellegrino Musto; Prof.MD Giovanni Martinelli; Carla Heise; Thomas Daniel; Rajesh Chopra; James Carmichael; Matthew Trotter; Anita K. Gandhi; Anjan Thakurta
Číslo abstraktu: 821
Kategorie: Maligní lymfomy a leukémie

631. Chronic Myeloid Leukemia: Biology and Pathophysiology, excluding Therapy: Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia

Role of the MSC-Derived Exosomal and Endogenous JAK2-SET/PP2A-Beta Catenin-Modulator Mir-300 in Leukemic Stem/Progenitor Proliferation and Survival in CML

Autoři: Giovannino Silvestri, Ph.D.; Lorenzo Stramucci, Ph.D.; Justin Ellis; Justine Yu; Jason Harb, Ph.D.; Paolo Neviani, Ph.D.; MD Guido Marcucci; Bc. Klára Šrůtová; Mgr. Kateřina Machová (Poláková), Ph.D.; Denis-Claude Roy; MD Peter Hokland; MD Michael W. Deininger, Ph.D.; MD Ravi Bhatia; Prof. Carlo Gambacorti-Passerini; Dragana Milojkovic; Dr. Alistair G. Reid, BSc, PhD; Prof. Jane F. Apperley, MBChB, MD, FRCP, FRCPath; Ferenc Livák, Ph.D.; MD Maria R. Baer; Rossana Trotta, Ph.D.; Prof. Dr. Danilo Perrotti, Ph.D.
Číslo abstraktu: 53
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Clinical and Molecular Predictors of Outcomes and Toxicities

The EUTOS Survival Score Is Preferable over the Sokal Score for Prognosis of Long-Term Survival of Patients with Chronic Myeloid Leukemia

Autoři: Dr. rer. biol. hum. Markus Pfirrmann, M.Sc.; MD Joerg Hasford; MD Susanne Saussele; MD Anna Turkina, PhD; dr n. med Witold Prejzner; MD Juan Luis Steegmann, PhD; MD Bengt Simonsson, PhD; MD Andrey Zaritsky (Zaritskey); Dr. Adriana Colita; MUDr. Daniela Žáčková, Ph.D.; MD Jeroen Janssen, PhD, MSc; MD Francisco Cervantes; prof. MUDr. Karel Indrák, DrSc.; Joelle Guilhot (Guillhot), PhD; Prof. Dr. Rüdiger Hehlmann; MD Michele Baccarani
Číslo abstraktu: 595
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Poster

Switch to Subsequent Line of Treatment in Children and Adolescents with Chronic Myeloid Leukemia (CML) Treated with Imatinib: Experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents (I-CML-Ped Study)

Autoři: Frédéric Millot; Joelle Guilhot (Guillhot), PhD; Prof. MD Meinolf Suttorp, PhD; MD Anne Sophie Meunier; MD Adalet Meral Gunes; prof. MUDr. Petr Sedláček, CSc.; MD Eveline S.J.M. de Bont, PhD; MD Chi Kong Li, MBBS; Krzysztof Kalwak; Birgitte Lausen; Srdjana Culic; MD Barbara De Moerloose; MD Andrea Biondi; MD Andre Baruchel, PhD
Číslo abstraktu: 1576
Kategorie: Maligní lymfomy a leukémie

Treatment and Outcome Analysis of 2,904 Pateints from the EUTOS Population Based Registry

Autoři: Dr. rer. biol. hum. Verena Sophia Hoffmann, BSc, M.A.; MD Michele Baccarani; MD Joerg Hasford; Dipl. Inf. Doris Lindörfer (Lindoerfer); MD Sonja Burgstaller; Dubravka Sertic; Dr. Paul A. Costeas; prof. MUDr. Jiří Mayer, CSc.; prof. MUDr. Karel Indrák, DrSc.; Prof. M.D. Hele Everaus (1953-), Ph.D.; MD Perttu (Pertu) Koskenvesa; Joelle Guilhot (Guillhot), PhD; Dr.rer.biol.hum Gabriele Schubert-Fritschle; MD Fausto Castagnetti; M.D. Francesco Di Raimondo; M.D. Sandra Lejniece, Ph.D.; M.D. Laimonas Griskevicius (Griškevičius); M.D. Noortje Thielen; MD Tomasz Sacha; MD Andrzej Hellmann, Ph.D.; MD Anna Turkina, PhD; MD Andrey Zaritsky (Zaritskey); Andrija Bogdanovic; MUDr. Zuzana Sninská; M.D. Irena Zupan, Ph.D.; Luis-Felipe Casado; MD Bengt Simonsson, PhD; Dr. Richard E. Clark, MBBS, MD, FRCP, FRCPath; MD Susanne Saussele; MD Andreas Hochhaus; Prof. Dr. Rüdiger Hehlmann
Číslo abstraktu: 2780
Kategorie: Maligní lymfomy a leukémie

Single-Cell Immune Signatures in Patients with Chronic Phase Chronic Myeloid Leukemia (CML) Treated with Nilotinib: An ENEST1st Sub Study

Autoři: Stein-Eric Gullaksen, MSc.; Jörn Skavland, Ph.D.; MD Krzysztof Warzocha, Ph.D.; Sonia Gavasso, Ph.D.; Vinko Tosevski, Ph.D.; M.D. Noortje Thielen; MUDr. Jaroslava Voglová; Prof. Augustin Ferrant; Univ.-Prof. Dr.med.univ. Werner Linkesch; Dr. Josef Thaler, Ph.D.; Dr. Alois Lang; MD Jesper Stentoft, PhD; MD Tobias Gedde-Dahl, PhD; M.D. Henrik Hjort-Hansen, Ph.D.; M.D. Waleed Majeed; Prof. Dr. Gregor Verhoef, Ph.D.; MD Andrzej Hellmann, Ph.D.; Prof. M.D. Georgi Mihaylov, Ph.D.; Claudia Dumrese, Ph.D.; Prof. MD Frank Giles, M.B.; MD Andreas Hochhaus; Sieghart Sopper, Ph.D.; MD Leif Stenke, PhD; Boris Labar, MD, PhD; MD Jeroen Janssen, PhD, MSc; MD Kimmo Porkka, PhD; MD Gert (J.) Ossenkoppele, PhD; MD Satu Mustjoki, PhD; MD Dominik Wolf; Prof. MD Bjoern-Tore Gjertsen, PhD
Číslo abstraktu: 4022
Kategorie: Maligní lymfomy a leukémie

DNA Based Detection and Quantification of BCR-ABL1 Gene Using Patient-Specific qPCR and Droplet Digital PCR Tests in Chronic Myeloid Leukemia

Autoři: Mgr. Hana Žižková (Říhová), Ph.D.; Bc. Eliška Motlová; Mgr. Karla Zemanová, Ph.D.; MUDr. Hana Klamová, CSc.; Mgr. Lenka Hovorková; prof. MUDr. Jan Zuna, Ph.D.; Jan Zach; MD Susanne Saussele; M.D. Francois-Xavier Mahon, Ph.D.; Mgr. Kateřina Machová (Poláková), Ph.D.
Číslo abstraktu: 4043
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Treatment-Free Remission, Mutations, and Prognosis

BCR-ABL Mutations in Chronic Myeloid Leukemia (CML) Patients (pts) with Failure and Warning to First- and Second-Line Tyrosine Kinase Inhibitor (TKI) Therapy: What Is the Advantage of Next-Generation Sequencing (NGS) over Conventional Sequencing?

Autoři: Simona Soverini; Caterina De Benedittis; MD Fausto Castagnetti; Gabriele Gugliotta; Manuela Mancini; MD Giorgina Specchia; Prof. Domenico Russo; MD Alessandra Iurlo; Massimiliano Bonifacio; MD Marzia Salvucci; Tamara Intermesoli; MD Paolo Avanzini; MD Sara Galimberti; MD Bruno Martino; MD Elena Maino; MD Anna Rita Scortechini; Mgr. Kateřina Machová (Poláková), Ph.D.; MD Giuseppe Saglio, PhD.; MD Fabrizio Pane; Prof. MD Gianantonio Rosti; MD Michele Baccarani; MD Michele Cavo; Prof.MD Giovanni Martinelli
Číslo abstraktu: 346
Kategorie: Maligní lymfomy a leukémie

634. Myeloproliferative Syndromes: Clinical: Poster I

A Study of the Role of Antiplatelet Therapy in the Prevention of Thrombosis in Patients with Calr-Mutated Low Risk Essential Thrombocythemia

Autoři: Dr. Alberto Alvarez-Larrán; MD Paola Guglielmelli; Eduardo Arellano-Rodrigo; MD Martin Griesshammer, Ph.D.; Chiara Paoli; Ana Kerguelen; Francisca Ferrer-Marin; Juan Carlos Hernández-Boluda; doc. MUDr. Bjorn Andreasson; MUDr. Jiří Schwarz, CSc.; Valentín García-Gutierrez; MD Rosa Ayala, Ph.D.; MD Pere Barba; María Teresa Gómez-Casares; MD Radek C. Skoda; Dr. Carmen Burgaleta; Stefanie Slot; MD Jan Samuelsson, Ph.D.; Alimam Samah; Yan Beauverd; Claire N. Harrison; MD Francisco Cervantes; MD Alessandro M. Vannucchi; MD Carlos Besses
Číslo abstraktu: 1602
Kategorie: Myeloproliferativní nemoci

Four Weeks Administration Schedule of Ropeginterferon Alfa-2b (AOP2014/P1101) in Polycythemia Very Patients Allows Maintaining of Efficacy with Favorable Toxicity Profile in the Phase I/II Peginvera Study

Autoři: MD Veronika Buxhofer-Ausch; MD Heinz Gisslinger; Dr. Josef Thaler, Ph.D.; MD Ernst Schloegl (Schlögl); MD Günther Gastl; MD Dominik Wolf; Robert Kralovics, PhD; Bettina Gisslinger; MD Sarita Ban; Prof.MUDr. Alexander Egle; M.D. Thomas Melchardt; MD Sonja Burgstaller; MD Ella Willenbacher; Martin Schalling, MSc.; MD Maria Theresa Krauth; Nicole C.C. Them, MSc.; Dr. Michael Zoerer (Zörer), PhD; Oliver Ammann-Mwathi; Pavla Kadlecová, PhD; MD Oleh Zagrijtschuk; Christoph Klade, PhD; MD Richard Greil, Ph.D.
Číslo abstraktu: 1603
Kategorie: Myeloproliferativní nemoci

634. Myeloproliferative Syndromes: Clinical: Poster III

Long Term Efficacy and Safety Results and Analysis of Dose Correlations from the Phase I/II Peginvera Study of Ropeginterferon Alfa-2b, a Novel IFNa-2b, in Polycythemia Vera Patient

Autoři: MD Heinz Gisslinger; MD Veronika Buxhofer-Ausch; Dr. Josef Thaler, Ph.D.; MD Ernst Schloegl (Schlögl); MD Günther Gastl; MD Dominik Wolf; Martin Schalling, MSc.; Bettina Gisslinger; MD Sarita Ban; Prof.MUDr. Alexander Egle; M.D. Thomas Melchardt; MD Sonja Burgstaller; MD Ella Willenbacher; MD Maria Theresa Krauth; Nicole C.C. Them, MSc.; Robert Kralovics, PhD; Dr. Michael Zoerer (Zörer), PhD; Oliver Ammann-Mwathi; Pavla Kadlecová, PhD; MD Oleh Zagrijtschuk; Christoph Klade, PhD; MD Richard Greil, Ph.D.
Číslo abstraktu: 4056
Kategorie: Myeloproliferativní nemoci

635. Myeloproliferative Syndromes: Basic Science II

Whole Exome Sequencing Identifies Novel MPL and JAK2 Mutations in Triple Negative Myeloproliferative Neoplasms

Autoři: Jelena D. Milosevic (Feenstra), Ph.D.; Harini Nivarthi, Ph.D.; MD Heinz Gisslinger; Emilie Leroy; Elisa Rumi; Ilyas Chachoua; Klaudia Bagienski; Mgr. Bc. Blanka Kubešová; Daniela Pietra, Ph.D.; Bettina Gisslinger; Roland Jäger; Doris Chen; Tiina Berg; Martin Schalling, MSc.; Michael Schuster, Ph.D.; Christoph Bock, Ph.D.; M.D. Stefan N. Constantinescu, Ph.D.; M.D. Mario Cazzola; Robert Kralovics, PhD
Číslo abstraktu: 606
Kategorie: Myeloproliferativní nemoci

636. Myelodysplastic Syndromes – Basic and Translational Studies: Poster I

The Integrated Immunological Signature of Refractory Cytopenia of Childhood (RCC)

Autoři: Demi de Winter; MD Marry M. van den Heuvel-Eibrink, PhD; Vincent H.J. Van der Velden, PhD; Dr. Anton W. (Ton) Langerak ; MD Jacques J.M. van Dongen, PhD; Prof. MD Michael Dworzak; MD Barbara De Moerloose; prof. MUDr. Jan Starý, DrSc.; Prof. MD Charlotte M. Niemeyer, PhD; Prof. MD Franco Locatelli, PhD; Prof. MD Henrik Hasle; MD Markus Schmugge (Schmugge-Liner); MD Christian Michel Zwaan, PhD; Prof. MD Rob Pieters, PhD
Číslo abstraktu: 1657
Kategorie: Myelodysplastický syndrom

636. Myelodysplastic Syndromes – Basic and Translational Studies: Poster III

Tracking the Somatic Mutations in Azacitidine-Treated MDS Patients Documents Clonal Development and AZA Responsiveness

Autoři: Doc. MUDr. Tomáš Stopka, Ph.D.; Mgr. Karina Vargová, Ph.D.; Mgr. Vojtěch Kulvait; RNDr. Jarmila Vargová (Podskočová); MUDr. Nina Dusílková; doc. MUDr. Anna Jonášová, Ph.D.
Číslo abstraktu: 4103
Kategorie: Myelodysplastický syndrom

Altered Expression of the Repair Genes in CD34+ Cells May be Responsible for Formation and Accumulation of Mutations in MDS Patients

Autoři: MUDr. Jan Válka; Mgr. Monika Běličková; Mgr. Jitka Veselá; Ing. Eliška Stará (Čechová); Barbora Pejšová; doc. MUDr. Anna Jonášová, Ph.D.
Číslo abstraktu: 4119
Kategorie: Myelodysplastický syndrom

637. Myelodysplastic Syndromes – Clinical Studies: Poster I

Clonal Mutational Landscape of Childhood Myelodysplastic Syndromes

Autoři: Emilia J. Kozyra; MD Shinsuke Hirabayashi; Victor Bengt Pastor Loyola, MSc.; Bartlomiej Przychodze, Ph.D.; Axel Karow; Albert Catala; MD Barbara De Moerloose; Prof. MD Michael Dworzak; Prof. MD Henrik Hasle; Riccardo Masetti; MD Markus Schmugge (Schmugge-Liner); Owen Smith; prof. MUDr. Jan Starý, DrSc.; Marek Ussowicz; MD Marry M. van den Heuvel-Eibrink, PhD; MUDr. Vít Campr, Ph.D.; MD Rita Devito; Pascale De Paepe, M.D.; MD Miguel Hernandez-Marti; Gitte Kerndrup; Roos Leguit; MD Jadwiga Maldyk; Prof. Dr. Maureen OxSullivan; MD Ingrid Simonitsch-Klupp; MD Irith Baumann; Prof. MD Franco Locatelli, PhD; M.D. Jaroslaw P. Maciejewski, Ph.D., FACP; MD Brigitte Strahm; Prof. MD Charlotte M. Niemeyer, PhD; MD Marcin W. Wlodarski
Číslo abstraktu: 1662
Kategorie: Myelodysplastický syndrom

Prognostic Impact of Transfusions Intensity on Survival and Development of Thrombocytopenia in Newly Diagnosed Lower-Risk MDS Patients Participating in the European Leukemianet EU-MDS Registry

Autoři: MD Louise de Swart; Dr. Tom Johnston; Alexandra Smith; MD Pierre Fenaux, PhD; Dr. Argyris Symeonidis, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.; MD Eva Hellström-Lindberg; MD Guillermo F Sanz, PhD; MD Reinhard Stauder; MD Luca Malcovati; MD Ulrich Germing; MD Gerwin A Huls, PhD; MD Mette Skov-Holm, PhD; M.D. Moshe Mittelman; MD Krzysztof Madry, PhD; MD Aurelia Tatic; MD Antonio Medina Almeida, PhD; M.D. Alexandar Savic, Ph.D.; Sophie Park; Odile Beyne-Rauzy; Raphael Itzykson; Corine van Marrewijk, PhD; MD David Bowen, Ph.D.; MD Theo de Witte, PhD
Číslo abstraktu: 1677
Kategorie: Myelodysplastický syndrom

637. Myelodysplastic Syndromes – Clinical Studies: Poster II

Labile Plasma Iron (LPI) Is a Clinical Indicator of Overt Iron Overload in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) from the European Leukemianet MDS Registry

Autoři: MD Louise de Swart; Chloé Reiniers; Tim Bagguley; MD David Bowen, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.; MD Eva Hellström-Lindberg; MD Aurelia Tatic; Dr. Argyris Symeonidis, Ph.D.; MD Gerwin A Huls, PhD; M.D. Panagiotis Panagiotidis; Hege Garelius; Dr. Dominic Culligan; Prof. MUDr. Marta Krejčí, Ph.D.; Corine van Marrewijk, PhD; Jackie Droste; Alexandra Smith; MD Dorine W. Swinkels, Ph.D.; MD Theo de Witte, PhD
Číslo abstraktu: 2865
Kategorie: Myelodysplastický syndrom

Prognostic Impact of Rare Single Abnormalities in Myelodysplastic Syndromes

Autoři: M.D. Julie Schanz; Heinz Tüchler (Tuechler); M.D. Francesc Solé, Ph.D.; MD Guillermo F Sanz, PhD; M.D. Guillermo Garcia Manero; Michelle Lebeau (LeBeau), Ph.D.; Prof. M.D. John M. Bennett; Marilyn L. Slovak, Ph.D.; MD Pierre Fenaux, PhD; MD Luca Malcovati; M.D. Mario Cazzola; Prof. Dr. Peter Valent; MD Kazuma Ohyashiki, PhD; M.D. Alessandro Levis; M.D. Mikkael A. Sekeres, M.S.; Dr. Sudhir Tauro, PhD, FRCPath; M.D. Silvia M. M. Magalhaes; M.D. Arjan A. van de Loosdrecht, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.; Prof. Dr. Michael Luebbert (Lübbert), Ph.D.; MD Reinhard Stauder; MD Eva Hellström-Lindberg; MD Tatjana Gindina; MD Ulrich Germing; Prof. M.D. Peter L. Greenberg; M.D. Detlef Haase, Ph.D.
Číslo abstraktu: 2879
Kategorie: Myelodysplastický syndrom

Safety of Lenalidomide (LEN) 10mg in Non-Del(5q) Versus Del(5q) in the Treatment of Patients (Pts) with Lower-Risk Myelodysplastic Syndromes (MDS): Pooled Analysis of Treatment-Emergent Adverse Events (TEAEs)

Autoři: MD Antonio Medina Almeida, PhD; MD Valeria Santini; MD Stephanie Gröpper; doc. MUDr. Anna Jonášová, Ph.D.; MD Norbert Vey, PhD; MD Aristoteles Giagounidis, PhD; MD Eva Hellström-Lindberg; Ghulam J. Mufti, DM, FRCP, FRCPath; MD Guillermo F Sanz, PhD; MD Barry Skikne; MD Albert Hoenekopp; Francis Séguy; Jianhua Zhong, Ph.D.; MD Pierre Fenaux, PhD
Číslo abstraktu: 2880
Kategorie: Myelodysplastický syndrom

Changes of Pro-Inflammatory Cytokines in Bone Marrow of MDS Patients in Response to Treatment with 5-Azacytidine

Autoři: Alena Moudrá, MSc.; Soňa Hubáčková, Ph.D.; Prof. MUDr. Jiří Bártek, Ph.D.; MUDr. Zdeněk Hodný, CSc.; doc. MUDr. Anna Jonášová, Ph.D.
Číslo abstraktu: 2895
Kategorie: Myelodysplastický syndrom

641. CLL: Biology and Pathophysiology, excluding Therapy: Characterizing and Targeting the Microenvironment in CLL

Next Generation Sequence Immunoprofiling of the T-Cell Repertoire in Chronic Lymphocytic Leukemia Supports Selection By Shared Antigenic Elements

Autoři: MD Anna Vardi, MSc.; Maria Karipidou; Aikaterini Gemenetzi; Elissavet Vlachonikola; Vasilis Bikos; Evangelia Stalika; Eva Koravou; Christos Maramis; Alexandra Siorenta; Dr. Achilles Anagnostopoulos; prof. RNDr. Šárka Pospíšilová, Ph.D.; Nikos Maglaveras, M.Sc., PH.D.; Ioanna Chouvarda; MD Kostas Stamatopoulos; Anastasia Hadzidimitriou
Číslo abstraktu: 618
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

641. CLL: Biology and Pathophysiology, excluding Therapy: Poster

ATM Mutations in Major Stereotyped CLL Subsets: Enrichment in Subset #2 is Associated with Unfavourable Outcome

Autoři: Mgr. Veronika Navrkalová, Ph.D.; Emma Young; Panagiotis Baliakas; Mgr. Lenka Radová, Ph.D.; Mgr. Karla Plevová, Ph.D.; Lesley-Ann Sutton; Larry Mansouri; Viktor Ljungström; Stavroula Ntoufa; Zadie Davis; Prof. MD Gunnar Juliusson, PhD; M.D. Karin Ekström Smedby, Ph.D.; MD Chrysoula Belessi; M.D. Panagiotis Panagiotidis; MD Frederic Davi, PhD; Dr. Anton W. (Ton) Langerak ; M.D. Paolo Ghia, Ph.D.; BSc. Jonathan C. Strefford, PhD; Prof. David Graham Oscier; MD Kostas Stamatopoulos; prof. RNDr. Šárka Pospíšilová, Ph.D.; Prof. MD Richard Rosenquist (Brandell), PhD; Doc. MUDr. Martin Trbušek, PhD
Číslo abstraktu: 1712
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Single Cell Analysis Proves the Coexistence of NOTCH1 and TP53 Mutations within the Same Cancer Cells in Patients with Chronic Lymphocytic Leukemia

Autoři: Mgr. Barbara Kantorová; RNDr. Jitka Malčíková, Ph.D.; Bc. Kamila Brázdilová; Mgr. Marek Borský; Mgr. Karla Plevová, Ph.D.; MUDr. Lenka Volková; Doc. MUDr. Martin Trbušek, PhD; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 2913
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Personalized Modeling of Disease Evolution in CLL: Does Statistical Significance Translate into Predictive Accuracy?

Autoři: Elisavet Chatzilari; Panagiotis Baliakas; Aliki Xochelli; Anastasios Maronidis; MD Anna Vardi, MSc.; Dr. Mattias Mattsson; Prof. Karin Larsson; Vassiliki Douka; Michalis Iskas; George Karavalakis; Apostolia Papalexandri; Carsten Utoft Niemann; MD Marco Montillo; Dr. Achilles Anagnostopoulos; Prof. David Graham Oscier; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Frederic Davi, PhD; Niki Stavroyianni; M.D. Paolo Ghia, Ph.D.; Anastasia Hadzidimitriou; Prof. MD Richard Rosenquist (Brandell), PhD; Dr. Spiros Nikolopoulos; MD Kostas Stamatopoulos; Dr. Yannis (Ioannis) Kompatsiaris
Číslo abstraktu: 2921
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Microenvironmental Interactions up-Regulate CD20 Expression in CLL B Cells through the CXCR4/SDF-1 Axis: Implications for CD20-Targeting Antibodies and the Use of BCR-Inhibitors in Combination

Autoři: Bc. Gabriela Pavlasová; Mgr. Václav Šeda; Mgr. Marek Borský; Kateřina Černá; Mgr. Jitka Osičková; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Matthew S. Davids; MD Jennifer R. Brown, Ph.D.; MUDr. Mgr. Marek Mráz, Ph.D.
Číslo abstraktu: 4124
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

EGR2 Mutations in Chronic Lymphocytic Leukemia: A New Bad Player

Autoři: Daniel Noerenberg; Emma Young; Viktor Ljungström; Larry Mansouri; Mgr. Karla Plevová, Ph.D.; Panagiotis Baliakas; Stuart Blakemore; M.D. Davide Rossi; MD Ruth Clifford; Mgr. Veronika Navrkalová, Ph.D.; Lesley-Ann Sutton; M.D. Karin Ekström Smedby, Ph.D.; Prof. MD Gunnar Juliusson, PhD; MD Chrysoula Belessi; M.D. Panagiotis Panagiotidis; MD Nicholas Chiorazzi; MD Frederic Davi, PhD; Dr. Anton W. (Ton) Langerak ; M.D. Anna Schuh, Ph.D.; MD Gianluca Gaidano, PhD; BSc. Jonathan C. Strefford, PhD; M.D. Paolo Ghia, Ph.D.; MD Kostas Stamatopoulos; prof. RNDr. Šárka Pospíšilová, Ph.D.; Prof. Dr. med. Thorsten Zenz; Prof. MD Richard Rosenquist (Brandell), PhD; Dr. Frederik Damm
Číslo abstraktu: 4126
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Single Cell Analysis of IG Genes in CLL: Cases with Multiple IGH Rearrangements Are Constituted of Several Independent Clones Even When Indistinguishable By Flow Cytometry

Autoři: Bc. Kamila Brázdilová; Mgr. Karla Plevová, Ph.D.; Mgr. Hana Skuhrová Francová; Mgr. Helena Kočková; MUDr. Magdalena Chmelíková; Mgr. Marek Borský; Mgr. Kateřina Burčková; Mgr. Barbara Kantorová; MvDr. Boris Tichý, Ph.D.; Dis. Hana Škabrahová; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. MUDr. Michael Doubek, Ph.D.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 4139
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Tp63 Contributes to the Apoptosis Resistant Phenotype in Aggressive Chronic Lymphocytic Leukemia

Autoři: Stavroula Ntoufa; Nikos Papakonstantinou; Despoina Papazoglou; Maria Tsagiopoulou; prof. RNDr. Šárka Pospíšilová, Ph.D.; Dr. Achilles Anagnostopoulos; Prof. MD Richard Rosenquist (Brandell), PhD; M.D. Paolo Ghia, Ph.D.; MD Kostas Stamatopoulos
Číslo abstraktu: 4142
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Reproducible Diagnosis of Chronic Lymphocytic Leukemia (CLL) By Flow Cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation Project

Autoři: Andy Rawstron, PhD; M.D. Karl-Anton Kreuzer; Asha Soosapilla; MUDr. Martin Špaček, Ph.D.; Peter C. Gambell; Neil McIver-brown; Katherina Psarra, MSc, PhD; MD Maria Arroz; Raffaella Milani; MD Javier de la Serna, Ph.D.; MD M. Teresa Cedena; MD Ozren Jaksic, PhD; Josep F. Nomdedéu; M.D. Carol Moreno; MD Gian Matteo Rigolin, Ph.D.; Prof. Antonio Cuneo; Preben Johansen; Prof. Hans Erik Johnsen; Prof. MD Richard Rosenquist (Brandell), PhD; Carsten Utoft Niemann; M.D. Wolfgang Kern; Dr. David A. Westerman, MBBS, FRACP, FRCPA; Prof. MUDr. Marek Trněný, CSc.; Stephen P. Mulligan, MBBS, PhD, FRACP, FRCPA; Peter Hillmen, M.B. ChB, Ph.D.; Prof. David Graham Oscier; Prof. MD Michael Hallek; M.D. Paolo Ghia, Ph.D.; Prof. Dr. Emili Montserrat
Číslo abstraktu: 4146
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

642. CLL: Therapy, excluding Transplantation: Poster II

Assessment of p53 and ATM Functionality in Chronic Lymphocytic Leukemia By Multiplex Ligation-Dependent Probe Amplification

Autoři: MD Doreen te Raa; Perry Moerland; Alexander Leeksma; Ingrid Derks; Martin Loden; Mgr. Veronika Navrkalová, Ph.D.; Doc. MUDr. Martin Trbušek, PhD; Dieuwertje M. Luijks; Prof. Dr. med. Thorsten Zenz; Anna Skowronska; MD Tatjana Stankovic, PhD; MD Marinus H.J. Van Oers, PhD; Eric Eldering, PhD; MD Arnon P. Kater, PhD
Číslo abstraktu: 2918
Kategorie: Maligní lymfomy a leukémie

Insights into the Management of Adverse Events in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Experience from the Phase 3 HELIOS Study of Ibrutinib Combined with Bendamustine/Rituximab

Autoři: M.D. Asher Alban Akmal Chanan-Khan; MD Paula Cramer; prof. MUDr. Fatih Demirkan; Dr. Graeme Fraser; Dr. Rodrigo Santucci Silva; MD Halyna Pylypenko; M.D. Sebastian Grosicki; MD Ann Janssens; M.D. Alexander S. Pristupa, Ph.D.; MD Andre Goy, MS; prof. MUDr. Jiří Mayer, CSc.; Marie-Sarah Dilhuydy; Dr. Javier Loscertales; Dr. Nancy L. Bartlett, MD; Dr. Abraham Avigdor; prof. Simon A. Rule; Steven Sun; Charles Phelps, MS; Michelle Mahler; Mariya Salman; Angela J. Howes; Prof. MD Michael Hallek
Číslo abstraktu: 2936
Kategorie: Maligní lymfomy a leukémie

Improvement of Quality of Response with Ibrutinib Plus Bendamustine/Rituximab Vs Placebo Plus Bendamustine/Rituximab for Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Autoři: MD Paula Cramer; M.D. Asher Alban Akmal Chanan-Khan; Dr. Graeme Fraser; prof. MUDr. Fatih Demirkan; Dr. Rodrigo Santucci Silva; MD Halyna Pylypenko; M.D. Sebastian Grosicki; MD Ann Janssens; MD Andre Goy, MS; prof. MUDr. Jiří Mayer, CSc.; Marie-Sarah Dilhuydy; Dr. Javier Loscertales; Dr. Nancy L. Bartlett, MD; Dr. Abraham Avigdor; prof. Simon A. Rule; Steven Sun; Charles Phelps, MS; Michelle Mahler; Mariya Salman; Michael Schaffer, Ph.D.; Sriram Balasubramanian, Ph.D.; Angela J. Howes; Prof. MD Michael Hallek
Číslo abstraktu: 2938
Kategorie: Maligní lymfomy a leukémie

642. CLL: Therapy, excluding Transplantation: Upfront CLL Therapy Excluding Transplantation

Results from the International, Randomized Phase 3 Study of Ibrutinib Versus Chlorambucil in Patients 65 Years and Older with Treatment-Naïve CLL/SLL (RESONATE-2TM)

Autoři: MD Alessandra Tedeschi; MD Paul M. Barr; MD Tadeusz Robak, PhD.; Dr. Carolyn Owen; M.D. Paolo Ghia, Ph.D.; MD Osnat Bairey; Peter Hillmen, M.B. ChB, Ph.D.; Dr. Nancy L. Bartlett, MD; Dr. Jianyong Li (Jian-Yong Li), Ph.D.; M.D. David Simpson, FRACP, FRCPA, MBChB; M.D. Sebastian Grosicki; Prof. Stephen Devereux, FRCP, FRCPath, PhD; Helen McCarthy, FRCP, FRCPath, PhD; MD Steven Coutre; MD Hang Quach; MD Gianluca Gaidano, PhD; MD Zvenyslava Maslyak; MD Don A. Stevens; MD Ann Janssens; MD Fritz C. Offner, PhD; prof. MUDr. Jiří Mayer, CSc.; Prof. Dr. Michael O'Dwyer; MD Andrzej Hellmann, Ph.D.; M.D. Anna Schuh, Ph.D.; MD Tanya Siddiqi; MD Aaron Polliack; Dr. Constantine S. Tam, MBBS; MD Michael Keating, MBBS; Deepali Suri, MS; Cathy Zhou, MS; Fong Clow, ScD; MD Lori Styles; MD Danelle F. James, MAS; MD Thomas J. Kipps, PhD; MD Jan A. Burger, Ph.D.
Číslo abstraktu: 495
Kategorie: Maligní lymfomy a leukémie

651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I

Assessment of the Parameters of Myeloma Bone Disease Signaling to the Extent of Skeletal Involvement, Bone Mineral Turnover and Activity of Multiple Myeloma

Autoři: Doc. MUDr.,Mgr. Jiří Minařík, PhD; MUDr. Zuzana Heřmanová, Ph.D.; MUDr. Pavla Petrová; Mgr. Jana Zapletalová; MUDr. Jan Hrbek; MUDr. Petra Puščiznová; Doc.MUDr. Jaroslav Bačovský, CSc.; MUDr. Tomáš Pika; Prof. MUDr. Miroslav Heřman, Ph.D.; Prof.MUDr. Vlastimil Ščudla, CSc.
Číslo abstraktu: 1754
Kategorie: Mnohočetný myelom

The Combination of SKY92 and ISS Provides a Powerful Tool to Identify Both High Risk and Low Risk Multiple Myeloma Cases, Validation in Two Independent Cohorts

Autoři: Martin van Vliet, Ph.D.; Joske Ubels, Ph.D.; Leonie de Best, MSc.; Dr. Erik van Beers, Ph.D.; MD Pieter Sonneveld, PhD.
Číslo abstraktu: 2970
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Advances in Newly Diagnosed and Relapsed Myeloma

Eloquent-2 Update: A Phase 3, Randomized, Open-Label Study of Elotuzumab in Combination with Lenalidomide/Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma - 3-Year Safety and Efficacy Follow-up

Autoři: Meletios Athanasios Dimopoulos, MD; Prof. MD Sagar Lonial; Darrell J. White; Prof. MD Philippe Moreau; MD Antonio P. Palumbo; Prof. M.D. Jesús San Miguel, Ph.D.; MD Ofer Shpilberg, MPH; MD Kenneth C. Anderson; M.D. Sebastian Grosicki; Prof.MUDr. Ivan Špička, PhD; Adam Walter-Croneck; Hila Magen-Nativ; MD Maria-Victoria Mateos, PhD; prof. MD Andrew Belch; MD Donna E. Reece, FRCPC; prof. MD Meral Beksac; MD Eric Bleickhardt; Valeriet Poulart; Jessica Katz; Anil K. Singhal; MD Paul Gerard Guy Richardson
Číslo abstraktu: 28
Kategorie: Mnohočetný myelom

Efficacy and Safety of Carfilzomib and Dexamethasone Vs Bortezomib and Dexamethasone in Patients with Relapsed Multiple Myeloma Based on Cytogenetic Risk Status: Subgroup Analysis from the Phase 3 Study Endeavor (NCT01568866)

Autoři: Wee Joo Chng; Prof. Dr. med. Hartmut Goldschmidt; Meletios Athanasios Dimopoulos, MD; Prof. MD Philippe Moreau; Douglas E. Joshua; MD Antonio P. Palumbo; MD Thierry Facon; Prof. MD Heinz Ludwig; prof. MUDr. Luděk Pour, Ph.D.; MD Ruben Niesvizky; M.D. Albert Oriol; MD Laura Rosiñol, PhD; M.D. Alexander Suvorov; MD Gianluca Gaidano, PhD; MUDr. Tomáš Pika; MD Katja C. Weisel; MD Vesselina Goranova-Marinova, PhD; Heidi H. Gillenwater; Nehal Mohamed; Shibao Feng; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 30
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Next Generation Agents, Novel Combinations, and Amyloidosis

Ixazomib, an Investigational Oral Proteasome Inhibitor (PI), in Combination with Lenalidomide and Dexamethasone (IRd), Significantly Extends Progression-Free Survival (PFS) for Patients (Pts) with Relapsed and/or Refractory Multiple Myeloma (RRMM): The Phase 3 Tourmaline-MM1 Study (NCT01564537)

Autoři: Prof. MD Philippe Moreau; MD Tamas Masszi, PhD; MD Norbert Grzasko, PhD; MD Nizar J. Bahlis; Markus Hansson; prof. MUDr. Luděk Pour, Ph.D.; MD Irwindeep Sandhu, FRCP; Dr. Peter Ganly; Bartrum W. Baker, MBChB, FRACP, FRCPA; Dr. Sharon Jackson, MBChB, FRACP, FRCPA; MD Anne Marie Stoppa; M.D. David Simpson, FRACP, FRCPA, MBChB; MD Peter Gimsing, DMSci; MD Antonio P. Palumbo; MD Laurent Garderet; MD Michele Cavo; M.D. Shaji Kumar; MD Cyrille Touzeau; M.D. Francis K. Buadi; M.D. Jacob P. Laubach; Jianchang Lin, Ph.D.; Deborah Berg, RN, MSN; Alessandra DiBacco; MD Ai-Min Hui, Ph.D.; MD Paul Gerard Guy Richardson
Číslo abstraktu: 727
Kategorie: Mnohočetný myelom

Impact of Prior Treatment on Patients with Relapsed Multiple Myeloma Treated with Carfilzomib and Dexamethasone Vs Bortezomib and Dexamethasone in a Subgroup Analysis of the Phase 3 Endeavor Study (NCT01568866)

Autoři: Prof. MD Philippe Moreau; Douglas E. Joshua; Wee Joo Chng; MD Antonio P. Palumbo; Prof. Dr. med. Hartmut Goldschmidt; prof. MUDr. Roman Hájek, CSc.; MD Thierry Facon; Prof. MD Heinz Ludwig; prof. MUDr. Luděk Pour, Ph.D.; MD Ruben Niesvizky; M.D. Albert Oriol; MD Laura Rosiñol, PhD; M.D. Alexander Suvorov; MD Gianluca Gaidano, PhD; MUDr. Tomáš Pika; MD Katja C. Weisel; MD Vesselina Goranova-Marinova, PhD; Heidi H. Gillenwater; Nehal Mohamed; Shibao Feng; Meletios Athanasios Dimopoulos, MD
Číslo abstraktu: 729
Kategorie: Mnohočetný myelom

Efficacy and Safety of Carfilzomib, Lenalidomide, and Dexamethasone Vs Lenalidomide and Dexamethasone in Patients with Relapsed Multiple Myeloma Based on Cytogenetic Risk Status: Subgroup Analysis from the Phase 3 Study Aspire (NCT01080391)

Autoři: Prof. Herve Avet-Loiseau; Dr. Rafael Fonseca; MD David Samuel diCapua Siegel, PhD; Meletios Athanasios Dimopoulos, MD; Prof.MUDr. Ivan Špička, PhD; MD Tamas Masszi, PhD; prof. MUDr. Roman Hájek, CSc.; MD Laura Rosiñol, PhD; MD Vesselina Goranova-Marinova, PhD; Prof. M.D. Georgi Mihaylov, Ph.D.; Doc. MUDr. Vladimír Maisnar, Ph.D.; MD Maria-Victoria Mateos, PhD; MD Michael (Luhua) Wang; MD Ruben Niesvizky; M.D. Albert Oriol; MD Andrzej Jakubowiak, PhD; Doc. MUDr.,Mgr. Jiří Minařík, PhD; MD Antonio P. Palumbo; MD William Bensinger; MD Visha Kukreti; M.D. Dina Ben-Yehuda; PharmD. Margaret E. Tonda; Mihaela Obreja; Prof. MD Philippe Moreau
Číslo abstraktu: 731
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Poster I

Carfilzomib and Dexamethasone Vs Bortezomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: Results of the Phase 3 Study Endeavor (NCT01568866) According to Age Subgroup

Autoři: MD Antonio P. Palumbo; Meletios Athanasios Dimopoulos, MD; Prof. MD Philippe Moreau; Wee Joo Chng; Prof. Dr. med. Hartmut Goldschmidt; prof. MUDr. Roman Hájek, CSc.; MD Thierry Facon; Prof. MD Heinz Ludwig; prof. MUDr. Luděk Pour, Ph.D.; MD Ruben Niesvizky; M.D. Albert Oriol; MD Laura Rosiñol, PhD; M.D. Alexander Suvorov; MD Gianluca Gaidano, PhD; MUDr. Tomáš Pika; MD Katja C. Weisel; MD Vesselina Goranova-Marinova, PhD; Heidi H. Gillenwater; Nehal Mohamed; Shibao Feng; Douglas E. Joshua
Číslo abstraktu: 1844
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Poster III

Serial Echocardiographic Assessment of Patients (Pts) with Relapsed Multiple Myeloma (RMM) Receiving Carfilzomib and Dexamethasone (Kd) Vs Bortezomib and Dexamethasone (Vd): A Substudy of the Phase 3 Endeavor Trial (NCT01568866)

Autoři: MD Stuart D. Russell; Dr. Alexander Lyon, BHF; MD Daniel J. Lenihan; Prof. MD Philippe Moreau; Douglas E. Joshua; Wee Joo Chng; MD Antonio P. Palumbo; Prof. Dr. med. Hartmut Goldschmidt; prof. MUDr. Roman Hájek, CSc.; MD Thierry Facon; Prof. MD Heinz Ludwig; prof. MUDr. Luděk Pour, Ph.D.; MD Ruben Niesvizky; M.D. Albert Oriol; MD Laura Rosiñol, PhD; M.D. Alexander Suvorov; MD Gianluca Gaidano, PhD; MD Vesselina Goranova-Marinova, PhD; Heidi H. Gillenwater; Nehal Mohamed; Shibao Feng; Meletios Athanasios Dimopoulos, MD
Číslo abstraktu: 4250
Kategorie: Mnohočetný myelom

721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment and Acute Transplant Toxicities: Poster

Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with High-Risk AML in Complete Remission: A Survey from the ALWP of the EBMT

Autoři: Florent Malard; MD Myriam Labopin, MS; MD Gernot Stuhler; MD Johanna Tischer; MD Joerg Thomas Bittenbring; Prof. Dr. med. Arnold Ganser; MD Nicolaus Kröger; MD Donald W. Bunjes, PhD; Dr. Christoph Schmid; prof. MUDr. Jiří Mayer, CSc.; MD Mauricette Michallet, Ph.D.; Prof. MD Michael Hallek; MD Bipin N. Savani; MD Mohamad Mohty, PhD; MD Arnon Nagler, MSc.
Číslo abstraktu: 3105
Kategorie: Maligní lymfomy a leukémie; Toxicita, nežádoucí účinky léčby

Defibrotide for Prophylaxis of Hepatic Veno-Occlusive Disease in Pediatric Hematopoietic Stem Cell Transplantation: Subanalysis Data from an Open-Label, Phase III, Randomized Trial

Autoři: M.D. Selim Corbacioglu; M.D. Ansgar Schulz; prof. MUDr. Petr Sedláček, CSc.; Dr. Bernd Gruhn; M.D. Simone Cesaro; Peter Bader
Číslo abstraktu: 4310
Kategorie: Maligní lymfomy a leukémie

723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster

Outcome of Patients with Myelofibrosis Relapsing after Allogeneic Stem Cell Transplant: A Retrospective Study By the Chronic Malignancies Working Party of EBMT

Autoři: MD Donal McLornan, Ph.D.; Richard Szydlo, Ph.D.; Anja van Biezen; Linda Koster; Evgeny Klyuchnikov; MD Andrea Bacigalupo; Prof. Dr. Michael Schleuning; Prof. Dr. med. Jürgen Finke; MUDr. Antonín Vítek; MD Andrew Peniket; M.D. Dietrich W. Beelen; Prof. MD Charles F. Craddock, BM, MRCP, MRCPath; Prof. Jane F. Apperley, MBChB, MD, FRCP, FRCPath; MD Wolfgang Andreas Bethge, MD; Prof. Dr. Didier Blaise; MD Dietger W Niederwieser; MD Liisa Volin, Ph.D.; Prof. Dr.med. Peter Dreger; MD Mauricette Michallet, Ph.D.; MD Arnon Nagler, MSc.; Prof. Dr. Renate Arnold, PhD; MD Eduardo Olavarria, Ph.D.; MD Nicolaus Kröger
Číslo abstraktu: 1958
Kategorie: Maligní lymfomy a leukémie

T-Prolymphocytic Leukemia Is Sensitive to Polyclonal T Cell-Derived Graft-Versus-Leukemia Effects: Evidence from Minimal Residual Disease Kinetics and TCR Repertoire Diversity Analyses

Autoři: MD Leopold Sellner; Prof. Dr.med. Peter Dreger; Max Schlitt; Henrik Knecht; Dietrich Herrmann; Bc. Thomas Reigl; Mgr. Adam Krejčí; Mgr. Vojtěch Bystrý; Dr. Nikos Darzentas, PhD; MD Michael Rieger; MD Sascha Dietrich; Prof. Dr. med. Thorsten Zenz; Prof.MD Anthony D. Ho, PhD, FRCP; MD Michael Kneba, PhD; MD Monika Brüggemann (Bruegemann), PhD
Číslo abstraktu: 3159
Kategorie: Maligní lymfomy a leukémie

731. Clinical Autologous Transplantation: Results

Autologous Transplantation Versus Cyclophosphamide-Lenalidomide-Prednisone Followed By Lenalidomide-Prednisone Versus Lenalidomide Maintenance in Multiple Myeloma: Long-Term Results of a Phase III Trial

Autoři: Francesca Gay; MD Valeria Magarotto; MD Maria Teresa Petrucci; M.D. Francesco Di Raimondo; prof. MUDr. Luděk Pour, Ph.D.; MD Tommaso Caravita; Prof.MUDr. Vlastimil Ščudla, CSc.; MD Anna Maria Cafro; Prof. MD Anna Marina Liberati; Stefano Spada; Doc. MUDr. Vladimír Maisnar, Ph.D.; Norbert Pescosta; Dr. Roberto Ria; M.D. Massimo Offidani; MD Sara Bringhen; Annalisa Bernardini; Francesca Patriarca; M.D. Paolo Corradini; Robert (Robin) Foa (Foà); MD Nicola Cascavilla; Lucio Catalano; MD Andrew Spencer; prof. MUDr. Roman Hájek, CSc.; MD Mario Boccadoro; MD Antonio P. Palumbo
Číslo abstraktu: 392
Kategorie: Mnohočetný myelom

Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Relapsing after Autologous Stem Cell Transplantation (ASCT): An Analysis of Patients Included in the Coral Study

Autoři: M.D. Eric Van den Neste, Ph.D.; MD Norbert Schmitz; M.D. Nicolas Mounier, Ph.D.; Devinder S Gill, MB ChB, MRCP (UK), FRCPath (Lond); Prof. MUDr. Marek Trněný, CSc.; MD Noel-Jean Milpied, Ph.D.; Prof. M.D. John Radford; Nicolas Ketterer; MD Ofer Shpilberg, MPH; M.D. Ulrich Dührsen (Duehrsen); Prof. Dr. David Ma; M.D. Josette Briere; M.D. Catherine Thieblemont, Ph.D.; MD Gilles Andre Salles, PhD; M.D. Craig H Moskowitz; M.D. Bertram Glass, PhD; MD Christian Gisselbrecht
Číslo abstraktu: 517
Kategorie: Maligní lymfomy a leukémie

Impact of Complete Response on Survival with Either Autologous Stem Cell Transplantation or Conventional Chemotherapy: Results of a Pooled Analysis of 5 Phase III Trials in Newly Diagnosed Multiple Myeloma Patients

Autoři: Roberto Mina; MD Alessandra Larocca; M.D. Massimo Offidani; MD Sara Bringhen; MD Tommaso Caravita; MD Valeria Magarotto; MD Lucia Pantani; M.D. Francesco Di Raimondo; Prof. M.D. Alberto Bosi (1950-); Dott.ssa Iolanda Donatella Vincelli; Paola Tacchetti; MD Gianluca Gaidano, PhD; Sonia Grandi; prof. M.D. Caterina Musolino; M.D. Chiara Cerrato; prof. MUDr. Luděk Pour, Ph.D.; Monica Astolfi; Dr. Giuseppe Rossi; MD Fausto Rossini; MD Maria Teresa Petrucci; Dr. Roberto Ria; Annalisa Pezzi; prof. MUDr. Roman Hájek, CSc.; MD Michele Cavo; MD Andrew Spencer; MD Mario Boccadoro; MD Antonio P. Palumbo
Číslo abstraktu: 927
Kategorie: Mnohočetný myelom

731. Clinical Autologous Transplantation: Results: Poster

Significant Survival Improvement with Maintenance in Patients Achieving a Complete Response: Pooled Analysis of 4 Italian Phase III Trials in Newly Diagnosed Multiple Myeloma Patients

Autoři: M.D. Chiara Cerrato; Francesca Gay; MD Maria Teresa Petrucci; MD Pellegrino Musto; MD Gianluca Gaidano, PhD; M.D. Massimo Offidani; Tommasina Guglielmelli; Marco Salvini; Francesca Patriarca; Elena Ponticelli; Gianpietro Semenzato; M.D. Francesco Di Raimondo; Roberto Mina; MD Nicola Cascavilla; M.D. Dina Ben-Yehuda; Daniela Oddolo, Ph.D.; M.D. Paolo Corradini; Lucio Catalano; Dr. Paolo Di Bartolomeo; prof. MUDr. Roman Hájek, CSc.; MD Andrew Spencer; MD Mario Boccadoro; MD Antonio P. Palumbo
Číslo abstraktu: 1974
Kategorie: Mnohočetný myelom

732. Clinical Allogeneic Transplantation: Results: Matched Related, Unrelated, and Alternative Donor Allograft Outcomes for Myeloid and Lymphoid Malignancies

Comparison of Matched-Sibling Donors Versus Unrelated Donors in Allogeneic Stem Cell Transplantation (allo-SCT) for Primary Refractory Acute Myeloid Leukemia (PRF AML): A Report of 1041 Patients from the Acute Leukemia Working Party of the EBMT

Autoři: Eolia Brissot; MD Myriam Labopin, MS; MD Matthias Stelljes; MD Gerhard Ehninger; MD Gernot Stuhler; Prof. Dr. med. Jürgen Finke; Prof. Dr. Hans-Jochem Kolb; Prof. Dr. med. Arnold Ganser; Dr. Kerstin Schäfer-Eckart; MD Nicolaus Kröger; MD Donald W. Bunjes, PhD; Stephan Mielke; MD Wolfgang Andreas Bethge, MD; MD Reza Tabrizi; Peter Kalhs; MD Igor W. Blau, Ph.D.; M.D. Bertram Glass, PhD; MUDr. Antonín Vítek; MD Martin Gramatzki; Ernst Holler, PhD; Dr. Christoph Schmid; MD Jordi Esteve, PhD; MD Arnon Nagler, MSc.; MD Mohamad Mohty, PhD
Číslo abstraktu: 196
Kategorie: Maligní lymfomy a leukémie

732. Clinical Allogeneic Transplantation: Results: Poster

Risk Factors Affecting Outcome of Transplantation in Pediatric Acute Lymphoblastic Leukemia: Results of the International BFM ALL SCT Study

Autoři: M.D. Adriana Balduzzi; M.D. Jean-Hugues Dalle, Ph.D.; MD Arjan Lankester, PhD; Prof. M.D. Isaac Yaniv; Prof. MD M. Akif Yesilipek; prof. MUDr. Petr Sedláček, CSc.; MD Marianne Ifversen, PhD; MD Sabina Šufliarska; MD Marc Bierings; M.D. Jacek Wachowiak, Ph.D.; M.D. Jacek Toporski, Ph.D.; Ulrike Poetschger, M.Sc.; Evgenia Glogova; Ingeborg Hirsch, BS; MD Christina Peters, Ph.D.
Číslo abstraktu: 2015
Kategorie: Maligní lymfomy a leukémie

Allogeneic Hematopoietic Transplantation in Patients with CLL: Results of a Large Disease-Specific Risk Factor Analysis

Autoři: MD Johannes Schetelig, MSC; Liesbeth C. de Wreede, Ph.D.; Michel Van Gelder; MD Niels Smedegaard Andersen, PhD; M.D. Carol Moreno; MUDr. Antonín Vítek; MUDr. Michal Karas; MD Mauricette Michallet, Ph.D.; Maciej J. Machaczka; MD Martin Gramatzki; M.D. Dietrich W. Beelen; Prof. Dr. med. Jürgen Finke; MD Álvaro Urbano-Ispizúa, Ph.D.; MD Liisa Volin, Ph.D.; Prof. Dr. Jakob Passweg; Prof. Dr.med. Peter Dreger; Anja Henseler, MSC; Anja van Biezen; Prof. Dr. Martin Bornhaeuser (Bornhäuser); MD Stefan Schoenland; MD Nicolaus Kröger
Číslo abstraktu: 3209
Kategorie: Maligní lymfomy a leukémie

902. Health Services and Outcomes Research – Malignant Diseases: Poster I

Generation of a Large Observational Pan-European Data Platform for Treatment and Outcome Patterns in Patients with Waldenstrom's Macroglobulinemia

Autoři: Prof. Dr. med. Christian Buske; Dr. Shalal Sadullah, FRCP, FRCPath; MD Efstathios Kastritis; Giulia Benevolo; Dr. Ramón García Sanz; MD Lukasz Bolkun, Ph.D.; MD Xavier Leleu, PhD; MD Wolfgang Willenbacher; prof. MUDr. Roman Hájek, CSc.; MD Ellen van der Spek, Ph.D.; Mei Cheng, Ph.D.; MD Thorsten Graef, PhD; Meletios Athanasios Dimopoulos, MD
Číslo abstraktu: 2096
Kategorie: Ostatní

902. Health Services and Outcomes Research – Malignant Diseases: Poster III

Registry of Monoclonal Gammopathies (RMG) in the Czech Republic

Autoři: MUDr. Jakub Radocha; prof. MUDr. Luděk Pour, Ph.D.; Prof.MUDr. Ivan Špička, PhD; Prof.MUDr. Vlastimil Ščudla, CSc.; MUDr. Evžen Gregora; MUDr. Hana Fraňková; prof. MUDr. Roman Hájek, CSc.; MUDr. Miroslava Schűtzová; MUDr. Michal Sýkora; MUDr. Petr Kessler; MUDr. Dagmar Adamová; MUDr. Marek Wróbel; Mgr. Lenka Sedlaříková; doc. RNDr. Sabina Ševčíková, Ph.D.; Doc.MUDr. Daniel Hořínek, Ph.D.; Mgr. Jana Pelcová; Bc. Lucie Brožová; RNDr. Jiří Jarkovský, Ph.D.; Doc. MUDr. Vladimír Maisnar, Ph.D.
Číslo abstraktu: 4514
Kategorie: Mnohočetný myelom