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Cancer Cells as Dynamic System – Molecular and Phenotypic Changes During Tumor Formation, Progression and Dissemination

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 6-11. DOI: 10.14735/amko20164S6.
Keywords: cellular reprogramming – cancer cell plasticity – cancer metabolism – tumor heterogeneity – cytoskeleton remodeling – metastasis – oncogenesis
Authors: Sommerová Lucia, Ondroušková Eva, Hrstka Roman

Multistep Process of Establishing Carcinoma Metastases

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 12-17. DOI: 10.14735/amko20164S12.
Keywords: metastasis – carcinoma – vascular endothelial growth factor A – epithelial-mesenchymal transition
Authors: Ondroušková Eva, Sommerová Lucia, Hrstka Roman

Mechanisms of Protein Homeostasis Regulation in Cancer Development

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 18-24. DOI: 10.14735/amko20164S18.
Keywords: molecular chaperones – heat-shock factor 1 – cancer – protein homeostasis
Authors: Trčka Filip, Müller Petr, Vojtěšek Bořivoj

Endoplasmic Reticulum Chaperones at the Tumor Cell Surface and in the Extracellular Space

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 25-30. DOI: 10.14735/amko20164S25.
Keywords: endoplasmic reticulum – glucose-regulated proteins – molecular chaperones – KDEL sequence – immunobiology
Authors: Brychtová Veronika, Vojtěšek Bořivoj

Rab Proteins, Intracellular Transport and Cancer

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 31-39. DOI: 10.14735/amko20164S31.
Keywords: Rab GTPases – protein transport – carcinogenesis
Authors: Černochová Radka, Holčáková Jitka, Nekulová Marta

Impact of HSP90 Inhibition on Viability and Cell Cycle in Relation to p53 Status

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 40-45. DOI: 10.14735/amko20164S40.
Keywords: breast cancer – cell cycle – chaperone – HSP90 – TP53 – p21 – p53 – NVP-AUY922
Authors: Pastorek Michal, Müller Petr, Vojtěšek Bořivoj

Molecular Mechanisms of Carcinogenesis of Epithelial Ovarian Cancers

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 46-53. DOI: 10.14735/amko20164S46.
Keywords: ovarian cancer – high-grade serous ovarian carcinoma – low-grade ovarian carcinoma – endometrioid carcinoma – mucinous carcinoma – malignant transformation – genetic instability
Authors: Müllerová Zuzana , Müller Tomáš, Skřivanová Kateřina, Vojtěšek Bořivoj, Müller Petr

Building Mass Spectrometry Spectral Libraries of Human Cancer Cell Lines

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 54-58. DOI: 10.14735/amko20164S54.
Keywords: biomarker – mass spectrometry – proteomics – digital biobanking – SWATH – protein quantification
Authors: Faktor Jakub, Bouchal Pavel

Utilization of Hydrogen/Deuterium Exchange in Biopharmaceutical Industry

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 59-63. DOI: 10.14735/amko20164S59.
Keywords: mass spectrometry – proteomics – protein conformation – drug discovery – drug industry – hydrogen/deuterium exchange
Authors: Coufalová Dominika, Vojtěšek Bořivoj, Hernychová Lenka

Novel Approaches in DNA Methylation Studies – MS-HRM Analysis and Electrochemistry

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 64-71. DOI: 10.14735/amko20164S64.
Keywords: DNA methylation – 5-methylcytosine – HRM analysis – melting temperature – DNA duplex – electrochemistry – nucleic acid hybridization
Authors: Bartošík Martin, Ondroušková Eva

The Role of PD-1/PD-L1 Signaling Pathway in Antitumor Immune Response

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 72-77. DOI: 10.14735/amko20164S72.
Keywords: programmed cell death pathway – tumor escape – PD-1 – PD-L1 – CD274
Authors: Zatloukalová Pavlína, Pjechová Mariana, Babčanová Soňa, Hupp Theodore Robert, Vojtěšek Bořivoj

Non-Small Cell Lung Cancer – from Immunobiology to Immunotherapy

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 78-87. DOI: 10.14735/amko20164S78.
Keywords: non-small cell lung cancer – immunotherapy – cancer vaccines – drug response biomarkers
Authors: Bílek Ondřej, Bohovicová Lucia, Demlová Regina, Poprach Alexandr, Lakomý Radek, Zdražilová Dubská Lenka

New Technologies for In Vivo Cancer Diagnostics

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 88-94. DOI: 10.14735/amko20164S88.
Keywords: surgery – cancer – tumors – molecular diagnostics – mass spectrometry – database
Authors: Hernychová Lenka, Coufalová Dominika, Michalová Eva, Nenutil Rudolf, Vojtěšek Bořivoj

Current Progresses in Developing PET Radiopharmaceuticals for Patients in the Czech Republic

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 95-100. DOI: 10.14735/amko20164S95.
Keywords: positron emission tomography – radiopharmaceuticals – L-methyl-11C-methionine – 18F-fluorocholine
Authors: Adam Jan, Demlová Regina, Řehák Zdeněk

Current Progresses in Developing PET Radiopharmaceuticals for Patients in the Czech Republic

Klinicka onkologie Journal. 2016; 29(Supplementum 4): 95-100. DOI: 10.14735/amko20164S95.
Keywords: positron emission tomography – radiopharmaceuticals – L-methyl-11C-methionine – 18F-fluorocholine
Authors: Adam Jan, Demlová Regina, Řehák Zdeněk

Glycine-N-methyltransferase and Malignant Diseases of the Prostate

Klinicka onkologie Journal. 2016; 29(5): 331-335. DOI: 10.14735/amko2016331.
Keywords: glycine – folic acid – metabolism – methylation – sarcosine
Authors: Heger Zbyněk, Eckschlager Tomáš, Stiborová Marie, Adam Vojtěch

Prognostic and Predictive Factors for Pancreatic Adenocarcinoma

Klinicka onkologie Journal. 2016; 29(5): 336-341. DOI: 10.14735/amko2016336.
Keywords: carcinoma pancreatic ductal − biological tumor markers − prognosis − prognostic factors
Authors: Karásek Petr, Hermanová Markéta

Treatment of Relapsed and Refractory Hodgkin Lymphoma – Recommendations of the Czech Hodgkin Lymphoma Study Group

Klinicka onkologie Journal. 2016; 29(5): 342-346. DOI: 10.14735/amko2016342.
Keywords: Hodgkin lymphoma – autologous stem cell transplantation – brentuximab vedotin – nivolumab
Authors: Móciková Heidi, Marková Jana, Gaherová Ľubica, Král Zdeněk, Sýkorová Alice, Belada David, Procházka Vít, Martínková Lenka, Papajík Tomáš, Kozák Tomáš

The Importance of MITF Signaling Pathway in the Regulation of Proliferation and Invasiveness of Malignant Melanoma

Klinicka onkologie Journal. 2016; 29(5): 347-350. DOI: 10.14735/amko2016347.
Keywords: neoplastic cell transformation – melanoma – MITF transcription factor
Authors: Urban Peter, Rabajdová Miroslava, Veliká Beáta, Špaková Ivana, Bolerázska Beáta, Mareková Mária

The Impact of High Protein Nutritional Support on Clinical Outcomes and Treatment Costs of Patients with Colorectal Cancer

Klinicka onkologie Journal. 2016; 29(5): 351-357. DOI: 10.14735/amko2016351.
Keywords: high protein oral nutritional support – colorectal cancer – perioperative care
Authors: Maňásek Viktor, Bezděk Kamil, Foltys Aleš, Klos Karel, Smitka Jan, Šmehlík David

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