2014 50th ASCO Annual Meeting - účast ČR

Breast Cancer - Triple-Negative/Cytotoxics/Local Therapy

BRCA-mutation status combined with BCL2 protein in prediction of relapse in triple-negative breast cancer (TNBC) treated with adjuvant anthracycline-based chemotherapy.

Autoři: MUDr. Kateřina Bouchalová (Špačková), Ph.D.; prof. MUDr. Marek Svoboda, Ph.D.; MUDr. Gvantsa Kharaishvili, Ph.D.; Mgr. Jana Vrbková, Ph.D.; Mgr. Lenka Radová, Ph.D.; doc. Mgr. Jan Bouchal, Ph.D.; RNDr. Radek Trojanec, Ph.D.; MUDr. Vladimíra Koudeláková (Palková); MUDr. Karel Cwiertka, Ph.D.; doc. MUDr. Marián Hajdúch, Ph.D.; prof. MUDr. Zdeněk Kolář, CSc.
Číslo abstraktu: 1132
Kategorie: Zhoubné nádory prsu

Developmental Therapeutics – Immunotherapy

Molecular characterization of immunogenic cell death triggered by the high hydrostatic pressure in human tumor cells.

Autoři: Mgr. Irena Moserová; Mgr. Iva Truxová; Pierre-Francois Cartron; Prof. MUDr. Jiřina Bartůňková, DrSc.; Prof. MUDr. Radek Špíšek, Ph.D.; PharmDr Jitka Fučíková, Ph.D.
Číslo abstraktu: e14008
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Gastrointestinal (Noncolorectal) Cancer

REGARD: A phase 3, randomized, double-blind trial of ramucirumab (RAM) and best supportive care (BSC) versus placebo (PL) and BSC in the treatment of metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma following disease progression (PD) on first-line platinum- and/or fluoropyrimidine-containing combination therapy: Age subgroup analysis.

Autoři: M.D. Charles S. Fuchs, MPH; MUDr. Jiří Tomášek, Ph.D.; Jae-Yong Cho, M.D., Ph.D.; Gianluca Tomasello; M.D. Chanchal Goswami, Pl; M.D. Lucas Vieira dos Santos; Dott. Giuseppe Aprile; Prof. M.D. David R. Ferry, Ph.D.; prof. MUDr. Bohuslav Melichar, Ph.D.; Mustapha Ali Tehfe; M.D. Eldar Topuzov, Ph.D.; Prof. M.D. John Raymond Zalcberg, MB BS, PhD, FRACP, FRACMA FAICD; M.D. Ian Chau; Josep Tabernero, MD; Yanzhi Hsu, Ph.D.; Jonathan D. Schwartz; Minori Koshiji; Prof. Dr. Howard Safran
Číslo abstraktu: 4057
Kategorie: Gastrointestinální nádory

Genitourinary (Prostate) Cancer

A phase 2 study of 99m Tc-trofolastat chloride (MIP-1404) SPECT/CT to identify and localize prostate cancer (PCa) in high-risk patients (pts) undergoing radical prostatectomy (RP) and extended pelvic lymph node (ePLN) dissection compared to histopathology: An interim analysis.

Autoři: Prof. M.D. Kevin Mark Slawin; Peter Tenke; M.D. Steven Joniau, Ph.D.; M.D. William John Ellis; MD Boris Alekseev; Istvan Buzogány; Sergey Mishugin; M.D. Eric A. Klein; MUDr. Josef Stolz, MBA; Prof. MUDr. Vladimír Študent, Ph.D.; Vsevolod Matveev; M.D. R. Jeffrey Karnes; M.D. David Frasier Jarrard; M.D. Bertram Emmanuel Yuh; M.D. Douglas Scherr; M.D. Edouard John Trabulsi; John Babich; Nancy Stambler; Thomas Armor; M.D. Robert Joseph Israel
Číslo abstraktu: e16003
Kategorie: Genitourinární nádory

Gynecologic Cancer

A phase II randomized open-label study of MM-121, a fully human monoclonal antibody targeting ErbB3, in combination with weekly paclitaxel versus weekly paclitaxel in patients with platinum-resistant/refractory ovarian cancers.

Autoři: Dr. Joyce Liu, MPH; M.D. Isabelle Ray-Coquard; Frédéric Selle; M.D. Andres Poveda; prof. MUDr. David Cibula, CSc.; Dr. Hal W. Hirte; Dr. Francesco Raspagliesi; Dr. Laurence Gladieff; Dr. Philipp Harter; Ilaria Schiavetto; M.D. Isabelle Marie Tabah-Fisch; Gavin MacBeath, Ph.D.; M.D. Akos Gabor Czibere, Ph.D.; Dr. R. Wendel Naumann; M.D. Robert Edward Coleman; M.D. Ignace Vergote, Ph.D.; M.D. Eric Pujade-Lauraine, Ph.D.
Číslo abstraktu: 5519
Kategorie: Zhoubné gynekologické nádory

Head and Neck Cancer

Final analysis: A randomized, blinded, placebo (P)-controlled phase III study of adjuvant postoperative lapatinib (L) with concurrent chemotherapy and radiation therapy (CH-RT) in high-risk patients with squamous cell carcinoma of the head and neck (SCCHN).

Autoři: Prof. M.D. Kevin J. Harrington; M.D. Stéphane Temam; Prof. M.D. Anil Keith D'Cruz; M.D. Minish Mahendra Jain; M.D. Ida D'Onofrio; M.D. Georgy M. Manikhas, Ph.D.; M.D. Geza Horvai; Prof. M.D. Yan Sun; M.D. Stefan Dietzsch; Assoc. Prof. Pavol Dubinský, MD, PhD; PharmDr. Magdalena Holečková; Prof. M.D. Hisham Mehanna; Dr. Iman El-Hariry, Ph.D.; Natalie Franklin; Nigel Biswas-Baldwin; M.D. Philippe Legenne; M.D. Paul Stephen Wissel; Thelma Netherway; M.D. Sergio Santillana; Prof. M.D. Jean-Henri Bourhis, Ph.D.
Číslo abstraktu: 6005
Kategorie: Nádory hlavy a krku

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-positive versus HPV-negative head and neck squamous cell carcinoma.

Autoři: Mgr. Simona Partlová; MUDr. Jan Bouček, Ph.D.; RNDr. Ruth Tachezy, Ph.D.; Prof. MUDr. Radek Špíšek, Ph.D.; Anna Fialová
Číslo abstraktu: 6010
Kategorie: Nádory hlavy a krku

Leukemia, Myelodysplasia, and Transplantation

Phase 3 study of oral lenalidomide as maintenance therapy for patients with B-cell chronic lymphocytic leukemia (CLL).

Autoři: M.D. Asher Alban Akmal Chanan-Khan; MD Andrey Zaritsky (Zaritskey); MD Miklós Egyed, PhD.; prof. MUDr. Samuel Vokurka, Ph.D.; M.D. Olga Samoylova; M.D. Anna Schuh, Ph.D.; M.D. David Simpson, FRACP, FRCPA, MBChB; MD Jay M. Mei, PhD; Natalia Oliveira; M.D. Oliver Kong; Robert (Robin) Foa (Foà)
Číslo abstraktu: TPS7125
Kategorie: Maligní lymfomy a leukémie

Lymphoma and Plasma Cell Disorders

Starlyte phase II study of coltuximab ravtansine (CoR, SAR3419) single agent: Clinical activity and safety in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL; NCT01472887).

Autoři: Prof. MUDr. Marek Trněný, CSc.; Prof. Dr. Gregor Verhoef, Ph.D.; Prof. M.D. Martin John Swinnerton Dyer; M.D. Dina Ben-Yehuda; Dott.ssa Caterina Patti; M.D. Miguel Canales; M.D. Andrés López, Ph.D.; M.D. Farrukh Awan; M.D. Paul G. Montgomery, FACP; Mgr. Mária Janíková, Ph.D.; Anna Maria Barbui; Kazimierz Sulek; M.D. Mária Hosé Terol; Prof. M.D. John Radford; Laure Siraudin; Laurence Hatteville; Sandrine Schwab; Corina Oprea; Alessandro M. Gianni
Číslo abstraktu: 8506
Kategorie: Maligní lymfomy a leukémie

Patient and Survivor Care

Integration of palliative care into standard oncology practice in the Czech Republic.

Autoři: MUDr. Marek Sochor; MUDr. Ondřej Sláma, Ph.D.; PhDr. Martin Loučka
Číslo abstraktu: e20546
Kategorie: Podpůrná onkologická léčba, výživa nemocných a ošetřovatelská péče

Postery

Immunotherapy (IT) with ch14.18/CHO for high-risk neuroblastoma: First results from the randomised HR-NBL1/SIOPEN trial.

Autoři: M.D. Ruth L Ladenstein, MBA; Ulrike Poetschger, M.Sc.; M.D. Roberto Luksch; Prof. M.D. Penelope Brock; M.D. Victoria Castel; Prof. M.D. Isaac Yaniv; M.D. Vassilios Papadakis, Ph.D.; Genevieve Laureys; MUDr. Josef Mališ; MD Walentyna Balwierz, PhD; M.D. Ellen Ruud, Ph.D.; Dr. Per Kogner; M.D. Henrik Schroeder, DrMsci; M.D. Maja Beck Popovic ; Dr. Peter F Ambros, Ph.D.; Guenter Schreier; Prof. M.D. Holger N. Lode, Ph.D.; Dr. Hans Loibner, Ph.D.; Prof. M.D. Andrew DJ Pearson; Dr. Dominique Valteau Couanet
Číslo abstraktu: 10026
Kategorie: Nádory dětského a adolescentního věku; zhoubné nádory mozku a CNS

Validation of the MIBG SIOPEN scoring method in two independent high-risk neuroblastoma trials.

Autoři: MD Ariane Boubaker; Ulrike Poetschger, M.Sc.; M.D. Bieke Lambert; M.D. Maria Rita Castellani; M.D. Zvi Bar-Sever; Aurore Oudoux; Prof. M.D. Anna Kamińska; MUDr. Katarína Táborská; M.D. Lorenzo Biassoni; M.D. Susan G. Kreissman; M.D. Gregory A. Yanik; Prof. M.D. Arlene Naranjo, Ph.D.; M.D. Marguerite T. Parisi; M.D. Barry L. Shulkin; M.D. Katherine K. Matthay; M.D. Julie R. Park; Dr. Dominique Valteau Couanet; M.D. Ruth L Ladenstein, MBA
Číslo abstraktu: 10029
Kategorie: Nádory dětského a adolescentního věku; zhoubné nádory mozku a CNS

Combined chemoimmunotherapy of castrate-resistant prostate cancer with dendritic-cell based vaccine DCVAC/Pca.

Autoři: MUDr. Michal Podrazil; RNDr. Daniela Rožková, Ph.D.; PharmDr Jitka Fučíková, Ph.D.; doc. PaedDr. RNDr. Stanislav Katina, Ph.D.; Prof. MUDr. Radek Špíšek, Ph.D.; Prof. MUDr. Jiřina Bartůňková, DrSc.
Číslo abstraktu: 3095
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Cancer immunotherapy of patients with the biochemical relapse of the prostate cancer using dendritic cell-based vaccine DCVAC/PCa.

Autoři: Prof. MUDr. Radek Špíšek, Ph.D.; MUDr. Michal Podrazil; doc. MUDr. Ladislav Jarolím, CSc.; RNDr. Daniela Rožková, Ph.D.; PharmDr Jitka Fučíková, Ph.D.; Anna Fialová; Prof. MUDr. Jiřina Bartůňková, DrSc.
Číslo abstraktu: 3099
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Phase II study of refametinib (BAY 86-9766), an allosteric dual MEK 1/2 inhibitor, and gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer

Autoři: M.D. Jean-Luc van Laethem, Ph.D.; prof. dr hab. n. med. Jacek Jassem; Volker Heinemann; M.D. Colin D. Weekes, Ph.D.; M.D. John A. Bridgewater; M.D. Stefano Cascinu; prof. MUDr. Bohuslav Melichar, Ph.D.; Dr. Marc Peeters, PhD; Paul J. Ross; Piotr Saramak; M.D. Marius Giurescu, Ph.D.; Vittorio Luigi Garosi; Katrin Roth; Anke Schulz; Michael Teufel; Barrett H. Childs; Prof. M.D. Hanno Riess
Číslo abstraktu: 4025
Kategorie: Gastrointestinální nádory

Progression-free survival (PFS) with lanreotide autogel/depot (LAN) in enteropancreatic NETs patients: The CLARINET extension study.

Autoři: Prof. M.D. Guillaume Cadiot, Ph.D.; Prof. M.D. Martyn E. Caplin, FRCP; Alison Langley; Prof. M.D. Alexandria T. Phan; Prof. Dr. Marianne E. Pavel, M.D.; Prof. M.D. Jaroslaw B. Cwikla; M.D. Markus Raderer; M.D. Guido Rindi, Ph.D.; Prof. M.D. Philippe B. Ruszniewski; MUDr. Eva Sedláčková, MBA; M.D. Lucy R. Wall ; Joelle Blumberg
Číslo abstraktu: 4071^
Kategorie: Gastrointestinální nádory

Lanreotide autogel/depot (LAN) treatment for carcinoid syndrome (CS) symptoms: Patient-reported outcomes (PROs) from the SYMNET study.

Autoři: Prof. M.D. Philippe B. Ruszniewski; Prof. M.D. Martyn E. Caplin, FRCP; M.D. Juan W. Valle; Catherine Lombard-Bohas; Graeme John Poston; M.D. Petros Perros, BSc, MBBS, FRCP; Doc. MUDr. Luboš Holubec (jr.), Ph.D., MBA; Prof. M.D. Gianfranco Delle Fave; Denis Michel Smith; Patricia Nicolli; Pascal Maisonobe; Philippe Atlan
Číslo abstraktu: 4111^
Kategorie: Gastrointestinální nádory

Impact of perioperative chemotherapy on survival in patients with advanced primary urethral cancer: Results of the international collaboration on primary urethral carcinoma.

Autoři: M.D. Georgios Gakis, F.E.B.U; M.D. Todd Matthew Morgan; M.D. Siamak Daneshmand; M.D. Kirk A. Keegan; M.D. Harras B. Zaid; MUDr. Jan Hrbáček; M.D. Bedeir Ali-El-Dein; M.D. Rebecca Helen Clayman; Lars Weissbach; M.D. Tilman Todenhoefer; Sigolene Galland; Dr. Hans-Martin Fristche; M.D. Michael Rink; M.D. Maximilian Burger; M.D. Sam Chang; prof. MUDr. Marek Babjuk, CSc.; Prof. M.D. George Niklaus Thalmann; Prof. M.D. Arnulf Stenzl; M.D. Jason Alexander Efstathiou, Ph.D.
Číslo abstraktu: 4587
Kategorie: Genitourinární nádory

Enzalutamide monotherapy: One-year extended follow-up of a phase 2 study in hormone-naive prostate cancer patients.

Autoři: Prof. M.D. Bertrand F. Tombal, Ph.D.; Prof. M.D. Michael Borre; M.D. Per Rathenborg; M.D. Patrick Werbrouck; Prof. M.D. Hendrik Van Poppel; Prof. M.D. Axel Heidenreich; Peter Iversen; M.D. Johan Braeckman; Doc. MUDr. Jiří Heráček, Ph.D.; M.D. Edwina Baskin-Bey; Taoufik Ouatas; M.D. Frank Perabo; De Phung; M.D. Mohammad Hirmand; M.D. Matthew Raymond Smith, Ph.D.
Číslo abstraktu: 5068
Kategorie: Genitourinární nádory

Immunohistochemical (IHC) prediction of lapatinib efficacy in HER2-positive advanced breast cancer patients.

Autoři: M.D. Renata Duchnowska, Ph.D.; Piotr Jan Wysocki; Konstanty Korski; Bogumila Czartoryska-Arlukowicz; M.D. Anna Niwińska, Ph.D.; Marlena Orlikowska; Barbara Radecka; M.D. Maciej Studzinski; Doc. MUDr. Regina Demlová, Ph.D.; Barbara Ziolkowska; Monika Merdalska; Lukasz Hajac; Paulina Mysliwiec; Dorota Zuziak; Sylwia Debska; Prof. Dr. István Lang; Malgorzata Foszczynska-Kloda ; Anna Kowalczyk; Wojciech Biernat; prof. dr hab. n. med. Jacek Jassem
Číslo abstraktu: 639
Kategorie: Zhoubné nádory prsu

E7080 (lenvatinib) in addition to best supportive care (BSC) versus BSC alone in third-line or greater nonsquamous, non-small cell lung cancer (NSCLC).

Autoři: MUDr. Libor Havel; Jong-Seok Lee; Ki Hyeong Lee; Prof. M.D. Paolo Bidoli; M.D. Joo-Hang Kim; Prof. M.D. David R. Ferry, Ph.D.; Young-Chul Kim, Ph.D.; M.D. Gyorgy Losonczy; Dr. Nicola Steele; M.D. In Sook Woo; Lea Forst; Yi Ma; Mark Joel Shelton; Fabrina Bologna; Brian Huber; M.D. Harish P. Dave, MBA
Číslo abstraktu: 8043
Kategorie: Zhoubné nádory plic a průdušek

A randomized double-blind phase III pivotal study of febuxostat (FEB) versus allopurinol (ALL) in the prevention of tumor lysis syndrome (TLS): Florence study.

Autoři: M.D. Michele Spina; Prof. M.D. Zoltán Zsolt Nagy, Ph.D.; Josep-Maria Ribera; Prof. M.D. Massimo Federico; Dr. Igor Aurer; M.D. Karin Jordan, Ph.D.; Dr. Gabriela Borsaru; M.D. Alexander S. Pristupa, Ph.D.; Prof. M.D. Alberto Bosi (1950-); M.D. Sebastian Grosicki; Nataliia L. Glushko; Dusan Ristic; Dr. János Jakucs; prof. MUDr. Jiří Mayer, CSc.; Prof. M.D. Eduardo Magalhães Rego; Dr. Simone Baldini; Simona Scartoni; Cecilia Simonelli; Angela Capriati; Carlo Alberto Maggi
Číslo abstraktu: 9641^
Kategorie: Podpůrná onkologická léčba, výživa nemocných a ošetřovatelská péče

Autologous dendritic cell vaccination (DCVAC/OvCa) added to standard of care therapy in three open-label randomized phase 2 studies in women with advanced stage ovarian cancer (OC).

Autoři: prof. MUDr. Lukáš Rob, CSc.; Prof. MUDr. Jiřina Bartůňková, DrSc.; prof. MUDr. David Cibula, CSc.; Pawel Knapp; Zuzana Náměstková; Prof. MUDr. Radek Špíšek, Ph.D.; MUDr. Jan Waclav; Prof. Dr. med. Peter Mallmann
Číslo abstraktu: TPS3134
Kategorie: Zhoubné gynekologické nádory

AUGMENT: A phase 3, randomized trial to compare efficacy and safety of lenalidomide plus rituximab versus placebo plus rituximab in patients with relapsed/refractory indolent non-Hodgkin lymphoma (NHL).

Autoři: Prof. M.D. John P. Leonard; M.D. John G. Gribben, DSC, FMedSci; Prof. MUDr. Marek Trněný, CSc.; M.D. Phillip Scheinberg; Nurgul Kilavuz; Meera Patturajan; Pierre Fustier
Číslo abstraktu: TPS8614
Kategorie: Maligní lymfomy a leukémie

NEMO: A phase 3 trial of binimetinib (MEK162) versus dacarbazine in patients with untreated or progressed after first-line immunotherapy unresectable or metastatic NRAS-mutant cutaneous melanoma.

Autoři: Keith Flaherty; prof. MUDr. Petr Arenberger, DrSc., MBA., FCMA; M.D. Paolo Antonio Ascierto (1964-); Jan Willem De Groot; M.D. Sigrun Hallmeyer; Prof. M.D. Georgina V. Long, BSc PhD MBBS FRACP; M.D. Michal Lotem; M.D. Maria Marples; Prof. M.D. Dirk Schadendorf; M.D. Alexander N. Starodub; M.D. Matthew Hiram Taylor; Pascal Wolter; M.D. Naoyai Yamazaki, Ph.D.; Ernesto Wasserman; James Ford; Marine Weill; Prof. M.D. Reinhard Dummer
Číslo abstraktu: TPS9102
Kategorie: Maligní melanom a nádory kůže

Sarcoma

A phase I/II study of sunitinib in young patients with advanced gastrointestinal stromal tumor.

Autoři: M.D. Arnauld Verschuur, Ph.D.; Prof. M.D. Jonathan C. Trent, Ph.D.; MUDr. Viera Bajčiová, CSc.; Aron D. Thall; Xun Lin; Reza Khosravan, Ph.D.; Antonella Ingrosso, ScD; Prof. M.D. Katherine A. Janeway
Číslo abstraktu: TPS10601
Kategorie: Sarcom