2008 50th ASH Annual Meeting - účast ČR

Acute Myeloid Leukemia

Wilms’ Tumor 1 Gene Mutations in Childhood Acute Myeloid Leukemia: A New Prognostic factor with Implications for MRD Detection

Autoři: MD Iris H.I.M. Hollink, PhD; MD Marry M. van den Heuvel-Eibrink, PhD; Martin Zimmermann, Ph.D.; V. Balgobind Brian; Susan T.C.J.M. Arentsen-Peters; Mariel Alders; MD Andre Willasch, PhD; MD Gertjan (J.L.) Kaspers, PhD; Prof.MUDr. Jan Trka, Ph.D.; MD Andre Baruchel, PhD; S.N. Siebold de Graaf ; MD Ursula Creutzig, PhD; Prof. MD Rob Pieters, PhD; MD Dirk Reinhardt, PhD; MD Christian Michel Zwaan, PhD
Číslo abstraktu: 144
Kategorie: Maligní lymfomy a leukémie

Prognostic Significance of Time to Relapse in Pediatric AML: Results from the International Randomised Phase III Study Relapsed AML 2001/01

Autoři: MD Gertjan (J.L.) Kaspers, PhD; Martin Zimmermann, Ph.D.; MD Dirk Reinhardt, PhD; Brenda Gibson; Rienk Tamminga; Hortensia Armendariz; Prof. MD Michael Dworzak; S. Ha; Prof. Liisa Hovi; Alexei Maschan; MD Andre Baruchel, PhD; M.D. Yves Bertrand; Bassem Razzouk; Carmelo Rizzari; MUDr. Petr Smíšek; Owen Smith; MD Batia Stark; MD Ursula Creutzig, PhD
Číslo abstraktu: 2976
Kategorie: Maligní lymfomy a leukémie

Long-Term Continuing Second Complete Remission (CCR2) despite Allogeneic Stem Cell Transplantation in CR1: Results from the International Randomised Phase III Study Pediatric Relapsed AML 2001/01

Autoři: MD Gertjan (J.L.) Kaspers, PhD; Martin Zimmermann, Ph.D.; MD Dirk Reinhardt, PhD; Brenda Gibson; Rienk Tamminga; Hortensia Armendariz; Prof. MD Michael Dworzak; S. Ha; Prof. Liisa Hovi; Alexei Maschan; MD Andre Baruchel, PhD; M.D. Yves Bertrand; Bassem Razzouk; Carmelo Rizzari; MUDr. Petr Smíšek; Owen Smith; MD Batia Stark; MD Ursula Creutzig, PhD
Číslo abstraktu: 2977
Kategorie: Maligní lymfomy a leukémie

Standard Dose Chemotherapy 3+7 Induces Complete Remission in Patients Over 80 Years Old with Single-Lineage Acute Myeloid Leukemias and Normal Karyotype

Autoři: MUDr. Petr Lemež, CSc.; MUDr. Jiřina Galíková; prof. Ing. Kyra Michalová, DrSc.; Alan MacWhannell; Doc.RNDr. Zuzana Zemanová, CSc.; MUDr. Jan Stejskal, Ph.D.
Číslo abstraktu: 4006
Kategorie: Maligní lymfomy a leukémie

GATA1 Mutations in Transient Leukemia and Myeloid Leukemia in

Autoři: Katarina Reinhardt, PhD; Katarina Boehmer; MD Jan-Henning Klusmann; Germeshausen Manuela; MD Annette Sander; MD Christine von Neuhoff; prof. MUDr. Jan Starý, DrSc.; Jürgens Heribert; Prof. Dr. med. Arnulf Pekrun; Sauerbrey Axel; Prof. MD Charlotte M. Niemeyer, PhD; Fleischhack Gudrun; MD Ursula Creutzig, PhD; MD Dirk Reinhardt, PhD
Číslo abstraktu: 923
Kategorie: Maligní lymfomy a leukémie

Alternative Donor Transplantation

Improved Outcome for Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) with Poor Risk Cytogenetics – Result from An Analysis on 172 Patients Receiving FLAMSA-RIC Conditioning for Allogeneic Stem Cell Transplantatioin (SCT)

Autoři: Pfeiffer Tim; Prof. Dr. Michael Schleuning; Eder Matthias; Prof. MUDr. Marta Krejčí, Ph.D.; Karin Kolbe; Prof. MD Christof Scheid, Ph.D.; Prof. Dr. Renate Arnold, PhD; Dr. Armin Gerbitz; MD Donald W. Bunjes, PhD; Ernst Holler, PhD; Bug Gesine; Christopeit Maximillian; MD Hildegard Greinix; MD Matthias Stelljes; MD Wolfgang Andreas Bethge, MD; Daniel V. Oruzio
Číslo abstraktu: 1971
Kategorie: Maligní lymfomy a leukémie

Standard and Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantations (HSCT) from Related and Unrelated Donors for Chronic Lymphocytic Leukemia (CLL). a Long-Term Follow-up (10 years) Study from the EBMT Registry. (CLL Sub-Committee on B

Autoři: MD Mauricette Michallet, Ph.D.; Hung Le Quoc; Prof. Dr.med. Peter Dreger; Sobh Mohamad; MD Dietger W Niederwieser; MUDr. Vladimír Koza (1954 - 2012); Tapani Ruutu; Prof. MD Nigel H. Russell; Verdonck Leo; MD Donald Milligan, MBChB; Nathalie Dhedin; doc. MUDr. Tomáš Kozák, Ph.D., MBA; Boogaerts Marc; Prof. Dr. med. Jürgen Finke; Tedone Nathalie; Anja van Biezen
Číslo abstraktu: 566
Kategorie: Maligní lymfomy a leukémie

Autologous Transplantation

Autologous Hematopoietic Stem Cell Transplantation (HSCT) for Autoimmune Diseases: 10 Years Experience from the European Group for Blood and Marrow Transplantation (EBMT) Working Party on Autoimmune Diseases

Autoři: MD Dominique Farge; MD Myriam Labopin, MS; Alan Tyndall; Fassas Athanasios; M.D. Gian Luigi Mancardi ; Jaap Van Laar; Ouyang Jian; doc. MUDr. Tomáš Kozák, Ph.D., MBA; John Moore; Kötter Ina; Virginie Chesnel; Marmont Alberto; Alois Gratwohl; Saccardi Riccardo
Číslo abstraktu: 164
Kategorie: Ostatní

Patients with Mature T-Cell Lymphoma Show High Relapse Rates after High Dose Therapy and Autologous Stem Cell Transplantation

Autoři: Nickelsen Maike; Canals Carmen; MD Norbert Schmitz; Kyriakou Charalampia; Monika Engelhardt; Thomas Relander; Univ.-Prof. Dr.med.univ. Werner Linkesch; MUDr. Vladimír Koza (1954 - 2012); Meloni Giovanna; MD Armando Lopez-Guillermo; Karel Indrac; MD Dolores Caballero; Hannes Wandt; Theorin Niklas; M.D. Bertram Glass, PhD
Číslo abstraktu: 774
Kategorie: Maligní lymfomy a leukémie

Basic Science and Clinical Practice in Blood Transfusion

Carbon Nanotubes Activate Platelets by Facilitating Extracellular Ca2+ Influx

Autoři: Jana Semberova; Dr. Ing. Karel Holada, Ph.D.; Olga Simakova; Monique P. Gelderman-Fuhrmann; Jan Simak
Číslo abstraktu: 992
Kategorie: Ostatní

Biologic Therapies for NHL (Excluding Pre-clinical Models)

The Rituximab Treament for Relapsed Follicular Lymphomas Changes the Duration of Subsequent Responses. the Analysis on Behalf of CLSG

Autoři: Prof. MUDr. Marek Trněný, CSc.; MUDr. Robert Pytlík, Ph.D.; MUDr. David Belada, Ph.D.; MUDr. Kateřina Kubáčková; MUDr. Milada Jankovská; doc. MUDr. Tomáš Papajík, CSc.; MUDr. Jan Pirnos; Mgr. Hana Krejčová
Číslo abstraktu: 1014
Kategorie: Maligní lymfomy a leukémie

Evaluation of Humoral Immune Responses to Vaccination with Tetanus Toxoid and KLH in Rituximab-Treated Follicular Non-Hodgkin’s Lymphoma Patients Compared to Healthy Volunteers

Autoři: Saville M. Wayne; Nancy Valente; Perea Rachelle; Gilder Kye; Judith Berlfein; Zyuzgin Ilya; MUDr. David Belada, Ph.D.; MD Andre Banat, MBA; Tudor Ciuleanu
Číslo abstraktu: 3066
Kategorie: Maligní lymfomy a leukémie

Blood Coagulation and Fibrinolytic Factors

First Experiences with the Measurement of Thrombin Generation (TGA) on the Ceveron® Alpha in the Routine Lab

Autoři: Wagner Lieselotte; Luddington Roger; Wiens Lilli; Alexandre Grigorov; Ingrid Hrachovinová; Binder Bernd
Číslo abstraktu: 4089
Kategorie: Ostatní

Bone Marrow Failure

The Frequency and Characteristics of the Ribosomal Protein L5 (RPL5) and Ribosomal Protein L11 (RPL11) Gene Mutations in Patients with Diamond-Blackfan Anemia in the Czech National Registry

Autoři: doc.MUDr. Dagmar Pospíšilová, Ph.D.; RNDr. Radek Čmejla, Ph.D.; RNDr. Jana Čmejlová, Ph.D.; Mgr. Helena Handrková, Ph.D.; prof. MUDr. Jan Starý, DrSc.; Cerna Zdenka
Číslo abstraktu: 3103
Kategorie: Ostatní

Clinical Care - Acute and Chronic GVHD, Infectious Complications, and Immune Reconstitution of Transplantation

New Characteristics of Liver Gvhd: Kinetics, and the Serum Levels of Enzymes Linked to Cholestasis

Autoři: prof. MUDr. Jiří Mayer, CSc.; MUDr. Jan Kamelander; Pospisil Zdenek; prof. MUDr. Michael Doubek, Ph.D.; Prof. MUDr. Marta Krejčí, Ph.D.
Číslo abstraktu: 4359
Kategorie: Ostatní

Clinical Results

Double Transplantation with Melphalan (200 mg/m2) Compared with Triple Transplantation with Intermediate Dose Melphalan (100 mg/m2) in Patients with Multiple Myeloma

Autoři: Prof. MD Heinz Ludwig; Prof.MUDr. Ivan Špička, PhD; Univ.-Prof. Dr.med.univ. Werner Linkesch; MD Richard Greil, Ph.D.; MD Hedwig Kasparu; Gunsilius Eberhard; Dr. Josef Thaler, Ph.D.; Drach Johannes; Ingrid Kuhn; Dr. Adalbert Weissmann (Weißmann); Hinke Axel
Číslo abstraktu: 3317
Kategorie: Mnohočetný myelom

Long-Term Outcomes of Autologous Transplantation in Multiple Myeloma: Benefit from the Newer Drugs Used in the Relapsed Setting

Autoři: prof. MUDr. Roman Hájek, CSc.; Prof. MUDr. Marta Krejčí, Ph.D.; prof. MUDr. Elena Tóthová, CSc.; doc. MUDr. Martin Mistrík, CSc., Ph.D.; Doc.MUDr. Jaroslav Bačovský, CSc.; MUDr. Miroslava Schűtzová; MUDr. Vladimír Koza (1954 - 2012); doc. MUDr. Tomáš Papajík, CSc.; Libuše Novosadová; MUDr. Hana Fraňková; Stavarova Yvetta; František Lehanka; MUDr. Milena Vránová; MUDr. Petr Kessler
Číslo abstraktu: 3331
Kategorie: Mnohočetný myelom

HLA-Identical Umbilical Cord Blood Transplantation from a Sibling Donor in Juvenile myelomonocytic Leukemia

Autoři: MD Andrica de Vries; Bredius Robbert; MD Arjan Lankester, PhD; MD Marc Bierings; Monika Trebo; prof. MUDr. Jan Starý, DrSc.; MD Marco Zecca; Prof. MD Franco Locatelli, PhD; Prof. MD Charlotte M. Niemeyer, PhD; MD Marry M. van den Heuvel-Eibrink, PhD
Číslo abstraktu: 4428
Kategorie: Maligní lymfomy a leukémie

Reduced Intensity Allogeneic Stem Cell Transplantation for Follicular Lymphoma Results in An Improved Progression Free Survival When Compared to Autologous Stem Cell Transplantation. An Analysis from the Lymphoma Working Party of the EBMT

Autoři: P. Robinson Stephen; Canals Carmen; Prof. Dr. Didier Blaise; Thomson Kirsty; Robert (Robin) Foa (Foà); Atienza Arturo Iriondo; Harousseau Jean-Luc; Catherine Cordonnier; MD Gordon Cook, PhD; Jean-Pierre Jouet; MD Jean-Yves Cahn, PhD; Charles Crawley; Michel Attal; Prof. MUDr. Marek Trněný, CSc.; MD Herve Tilly; Anna Sureda, MD
Číslo abstraktu: 458
Kategorie: Maligní lymfomy a leukémie

Clinical Transplantation: Acute GVHD Prevention and Risk Assessment

A Randomized Prospective Multicenter Phase III Trial Comparing Standard GvHD Prophylaxis with Cyclosporine and Methotrexate with Additional Pretransplant ATG Fresenius (ATG-F) in Allogeneic Stem Cell Transplantation from Matched Unrelated Donors

Autoři: Prof. Dr. med. Jürgen Finke; MD Wolfgang Andreas Bethge, MD; Claudia Schmoor; Ottinger Hellmut; MD Matthias Stelljes; Prof. Dr. Axel R. Zander; MD Liisa Volin, Ph.D.; Dominik Heim; M.D. Rainer Schwerdtfeger; Karin Kolbe; prof. MUDr. Jiří Mayer, CSc.; M.D. Johan Maertens, Ph.D.; Univ.-Prof. Dr.med.univ. Werner Linkesch; Ernst Holler, PhD; MUDr. Vladimír Koza (1954 - 2012); Prof. Dr. Martin Bornhaeuser (Bornhäuser)
Číslo abstraktu: 57
Kategorie: Ostatní

Contribution of Myeloid and Progenitor Cells to Tissue Regeneration and Inflammation

Transcription Factors PU.1 and EGR2 Inhibits the Oncogenic Microrna Cluster Mir-17-92 during Macrophage Differentiation

Autoři: Mgr. Vít Pospíšil; Mgr. Karina Vargová, Ph.D.; Mgr. Pavel Burda, Ph.D.; Mgr. Juraj Kokavec; Prof. MUDr. Emanuel Nečas, DrSc.; Jiri Zavadil, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 473
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Disordered Gene Expression in Hematologic Malignancy, Including Epigenetic Regulation

Evidence for An Anti-Cancer Barrier in a Mixed Lineage Leukemia Mouse Model in Vivo

Autoři: Mgr. Sylvia Takáčová, Ph.D.; Prof. MUDr. Jiří Bártek, Ph.D.; Ing. Lucie Piterková; Robert K. Slany; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 3347
Kategorie: Maligní lymfomy a leukémie

Targeted Therapy of AML1/ETO-Positive AML Cells in Experimental Model

Autoři: MUDr. Michal Zápotocký; Mgr. Júlia Starková, Ph.D.; MUDr. Ester Mejstříková, Ph.D.; Prof. MUDr. Karel Smetana, DrSc.; Prof.MUDr. Jan Trka, Ph.D.
Číslo abstraktu: 3358
Kategorie: Maligní lymfomy a leukémie

Expression Profile of Selected HOX Genes in Different Childhood ALL Subtypes

Autoři: Blanka Vicenova; Krejci Ondrej; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Kateřina Mužíková; Mgr. Júlia Starková, Ph.D.; RNDr. Martin Pospíšek, PhD.; M.D. Harry A. Drabkin; Prof.MUDr. Jan Trka, Ph.D.
Číslo abstraktu: 4462
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Molecular Variability of FLT3/ITD Mutants and Their Impact on the Differentiation Program of 32D Cells: Implications for the Biological Properties of AML Blasts

Autoři: MUDr. Soňa Peková, Ph.D.; Michal Dvorak; Robert Ivanek; Dr. Sabrina Rueggeberg; Leicht Stefan; doc. MUDr. Tomáš Kozák, Ph.D., MBA; Jiri Vrba; MUDr. Jiří Schwarz, CSc.; prof. MUDr. Petr Cetkovský, Ph.D.; Doc.MUDr. Miroslav Průcha, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.
Číslo abstraktu: 4480
Kategorie: Ostatní

Ex Vivo Expansion, Mobilization and Engraftment

Correlation of Cytokines Levels and Adhesion Molecules Expression with Stem Cell Mobilization Efficacy in Healthy Donors

Autoři: MUDr. Daniel Lysák; MUDr. Alexandra Jungová; Jindra Vrzalová; Doc. MUDr. Luboš Holubec (jr.), Ph.D., MBA; MUDr. Vladimír Koza (1954 - 2012)
Číslo abstraktu: 3466
Kategorie: Ostatní

Experimental Transplantation - GVHD and GVL

Molecular Identification of Individual T Cell Clones Specific for Graft- Versus-Leukemia Reaction

Autoři: Mgr. Veronika Foltánková; RNDr. Eva Matějková; RNDr. Milan Bartoš, Ph.D.; RNDr. Miloš Dendis; MUDr. Dana Novotná; prof. MUDr. Jiří Mayer, CSc.; Prof. MUDr. Jaroslav Michálek, Ph.D.
Číslo abstraktu: 1249
Kategorie: Maligní lymfomy a leukémie

Health Services and Outcomes Research

A Prospective Study on the Feasibility of Related and Unrelated Donor Search and Hematopoietic Cell Transplantation for Adults with Acute Leukemia at 31 European Transplant Centers

Autoři: Rocha Vanderson; Arat Mutlu; MUDr. Vladimír Koza (1954 - 2012); MD Norbet Claude Gorin; Prof. Augustin Ferrant; Dr. Kerstin Schäfer-Eckart; Ebeling Freja; Dr. Giuseppe Milone; Paolo de Fabritiis; Verdonck Leo; Prof. M.D. Alberto Bosi (1950-); MD Jordi Esteve, PhD; Allione Bernardino; M.D. Johan Maertens, Ph.D.; Olivieri Attilio
Číslo abstraktu: 2385
Kategorie: Maligní lymfomy a leukémie

Hematopoiesis

Influence of Prion Gene Downregulation by RNAi on Erythroid Differentiation in Vitro. First Insight

Autoři: Martin Panigaj; Hana Glierova; Dr. Ing. Karel Holada, Ph.D.
Číslo abstraktu: 1338
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Gata1 Regulates Erythroid Transcription by Cooperating with Chromatin Remodeling Protein Snf2h

Autoři: RNDr. Jarmila Vargová (Podskočová); Mgr. Pavel Burda, Ph.D.; Mgr. Karina Vargová, Ph.D.; Mgr. Juraj Kokavec; Mgr. Nikola Čuřík, Ph.D.; Jiri Zavadil, Ph.D.; Arthur I. Skoultchi, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 4759
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Hogkin Lymphoma - Interim PET in Lymphoma

Dose-Intensified Combined Modality Treatment with 2 Cycles of BEACOPP Escalated Followed by 2 Cycles of ABVD and Involved Field Radiotherapy (IF-RT) Is Superior to 4 Cycles of ABVD and IFRT in Patients with Early Unfavourable Hodgkin Lymphoma (HL): A

Autoři: MD Peter Borchmann, PhD; Prof. MD Andreas Engert; Annette Pluetschow; MD Michael Fuchs; MUDr. Jana Marková; MD Andreas Lohri; MUDr. Zdeněk Král, Ph.D.; MD Richard Greil, Ph.D.; Prof. Dr. Max S Topp; Villalobos Matthias; Jose Zijlstra, MD; M.D. Martin Soekler (Sökler); Prof. Harald Stein; Eich Hans Theodor; Rolf Peter Mueller; MD Volker Diehl
Číslo abstraktu: 367
Kategorie: Maligní lymfomy a leukémie

Chronic Lymphocytic Leukemia - Biology and Pathophysiology, Excluding Therapy

High Expression of LAG3, LPL and ZAP-70 Genes in B-CLL Strongly Correlates with Unmutated IgVH and Early Therapy Requirement

Autoři: Mgr. Jana Kotašková, Ph.D.; MUDr. Mgr. Marek Mráz, Ph.D.; MvDr. Boris Tichý, Ph.D.; RNDr. Jitka Kabáthová; RNDr. Jitka Malčíková, Ph.D.; Doc. MUDr. Martin Trbušek, PhD; Mgr. Hana Skuhrová Francová; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 2059
Kategorie: Maligní lymfomy a leukémie

TP53 Abnormalities in Chronic Lymphocytic Leukemia Exhibit a Disease Specific Profile: Meta-Analysis of 270 Mutations

Autoři: Prof. Dr. med. Thorsten Zenz; Jana Smadova; Dominik Vollmer; Doc. MUDr. Martin Trbušek, PhD; Benner Axel; Habe Sonja; Tina Denzel; RNDr. Jitka Malčíková, Ph.D.; Sim Truong; Nancy Patten, PhD; Prof. David Graham Oscier; Ibbotson Rachel; Anne Gardiner; Student Tracy Ian, PhD; Dr. Ke Lin; Prof. Andrew R Pettitt, MRCP, PhD; prof. RNDr. Šárka Pospíšilová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 2077
Kategorie: Maligní lymfomy a leukémie

Prognostic Stratification of Patients with Chronic Lymphocytic Leukemia Based on Quantitative Flow Cytometry Evaluation of ZAP-70 Versus Homology of IgVH Plot

Autoři: prof. MUDr. Martin Klabusay, Ph.D.; Ing. Viera Kuhrová; MUDr. Viera Hrabčáková (roz. Kohútová); MUDr. Petr Čoupek; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 2081
Kategorie: Maligní lymfomy a leukémie

Disruption of a Functional Relationship Between PU.1 and Mir-155 during the Pathogenesis of Chronic Lymphocytic Leukemia (CLL)

Autoři: Doc. MUDr. Tomáš Stopka, Ph.D.; Mgr. Karina Vargová, Ph.D.; MUDr. Adéla Berková; Mgr. Juraj Kokavec; Prof. MUDr. Marek Trněný, CSc.; Jiri Zavadil, Ph.D.
Číslo abstraktu: 3148
Kategorie: Maligní lymfomy a leukémie

Angiopoietin-2 mRNA Expression Is Elevated in Chronic Lymphocytic Leukemia Patients with Poor Prognostic Features

Autoři: Mgr. Filip Vrbacký; MUDr. Lukáš Smolej, Ph.D.; Mgr. Vladimíra Vroblová, Ph.D.; MUDr. Soňa Peková, Ph.D.; MUDr. Monika Hrudková; Doc.RNDr. Miroslav Pecka, CSc.; Prof.MUDr. Jaroslav Malý, CSc.
Číslo abstraktu: 4182
Kategorie: Maligní lymfomy a leukémie

Circulating Angiogenic Cytokines in Chronic Lymphocytic Leukemia: Relationship to Modern Prognostic Factors and Effect of Fludarabine-Based Treatment

Autoři: MUDr. Lukáš Smolej, Ph.D.; Doc.RNDr. Ctirad Andrýs, Ph.D.; MUDr. Soňa Peková, Ph.D.; Mgr. Lenka Kučerová; MUDr. Monika Hrudková; MUDr. David Belada, Ph.D.; Prof.MUDr. Jaroslav Malý, CSc.
Číslo abstraktu: 4186
Kategorie: Maligní lymfomy a leukémie

Chronic Lymphocytic Leukemia - Therapy, Excluding Transplantation

Clinical Outcome of B-Cell Chronic Lymphocytic Leukemia Following Alemtuzumab Therapy: Retrospective Study within Various Cytogenetic Risk Categories

Autoři: Michael Fiegl; Martin Erdel; Tinhofer Inge; Hopfinger Georg; Karin Eigenberger; Falkner Florian; Andreas Falkner; MUDr. Yvona Brychtová, Ph.D.; MUDr. Anna Panovská; prof. MUDr. Michael Doubek, Ph.D.; M.D. August Zabernigg; Sodia Sigrun; Mühlberger Helmut; Christa Fonatsch, Ph.D.; MD Günther Gastl; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 3164
Kategorie: Maligní lymfomy a leukémie

Immunochemotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Versus Fludarabine and Cyclophosphamide (FC) Improves Response Rates and Progression-Free Survival (PFS) of Previously Untreated Patients (pts) with Advanced Chron

Autoři: Prof. MD Michael Hallek; Guenter Fingerle-Rowson; MD Anna-Maria Fink; Dipl.Math. Raymonde Busch, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; Hensel Manfred; Hopfinger Georg; MD Georg Hess; von Gruenhagen Ulrich; Manuela A. Bergmann; MBBS John V. Catalano, FRACP FRCPA; Pier Luigi Zinzani; MD Federico Caligaris Cappio; Prof. John Francis Seymour, MD, PhD, MBBS, FRACP
Číslo abstraktu: 325
Kategorie: Maligní lymfomy a leukémie

Ofatumumab (HuMax-CD20), a Novel CD20 Monoclonal Antibody, Is An Active Treatment for Patients with CLL Refractory to Both Fludarabine and Alemtuzumab or Bulky Fludarabine-Refractory Disease: Results from the Planned Interim Analysis of An Internatio

Autoři: MD Anders Österborg, PhD; MD Thomas J. Kipps, PhD; prof. MUDr. Jiří Mayer, CSc.; MD Stephan Stilgenbauer; Catherine D. Williams, MBBS, MRCP, FRCPath; Andrzej Hellmen; MD Tadeusz Robak, PhD.; R. Furman Richard; Peter Hillmen, M.B. ChB, Ph.D.; Prof. MUDr. Marek Trněný, CSc.; Prof. M.D. Martin John Swinnerton Dyer; MBBS, MD Swaminathan Padmanabhan; doc. MUDr. Tomáš Kozák, Ph.D., MBA; MD Geoffrey (W.) Chan; Davis Ran
Číslo abstraktu: 328
Kategorie: Maligní lymfomy a leukémie

Chronic Myeloid Leukemia - Biology and Pathophysiology Excluding Therapy

Differential Expression of miRNAs during the Course of Chronic Myeloid Leukemia

Autoři: Mgr. Kateřina Machová (Poláková), Ph.D.; Mgr. Tereza Lopotová; MUDr. Hana Klamová, CSc.; RNDr. Jana Moravcová, CSc.
Číslo abstraktu: 1082
Kategorie: Maligní lymfomy a leukémie

Chronic Myeloid Leukemia - Therapy

Successful Treatment with Imatinib Mesylate Significantly Decreases Plasma Levels of Vascular Endothelial Growth Factor (VEGF) and Soluble Endoglin (sCD105) but Not Basic Fibroblast Growth Factor (bFGF) or Angiopoietin-2 (Ang-2) in Patients with Chro

Autoři: MUDr. Lukáš Smolej, Ph.D.; Doc.RNDr. Ctirad Andrýs, Ph.D.; MUDr. Jaroslava Voglová; MUDr. Petra Bělohlávková; Ing. Jana Rabasová; Doc.Pharm.Dr. Martin Beránek, Ph.D.; Prof.MUDr. Jaroslav Malý, CSc.
Číslo abstraktu: 4252
Kategorie: Maligní lymfomy a leukémie

Imatinib Plasma Levels Correlate with Molecular Response in CML Patients

Autoři: Mgr. Šárka Rožmanová ; RNDr., Mgr. David Friedecký, Ph.D.; Adriana Polynkova; prof. MUDr. Edgar Faber, CSc.; MUDr. Peter Rohoň; Doc.RNDr. Tomáš Adam, Ph.D.; Prof. RNDr. Mgr. Marie Jarošová, CSc.; prof. MUDr. Karel Indrák, DrSc.
Číslo abstraktu: 4268
Kategorie: Maligní lymfomy a leukémie

Incorporation of Rituximab into Clinical Management of NHL

The Addition of Rituximab Eliminates the Negative Prognostic Impact of PMBCL Compared to DLBCL in Young Patients with CD20-Positive Aggressive Lymphomas Receiving a CHOP-Like Chemotherapy: Results of a Subgroup Analysis of the Mabthera International

Autoři: Prof. MUDr. Marek Trněný, CSc.; MD Michael Rieger; MD Anders Österborg, PhD; Ruth Pettengel, MBchB, FRACP, PhD; Darrell J. White; Devinder S Gill, MB ChB, MRCP (UK), FRCPath (Lond); MD Jan Andrzej Walewski, Ph.D.; Kuhnt Evelyn; Markus Loeffler; MD Michael Pfreundschuh; Prof.MD Anthony D. Ho, PhD, FRCP
Číslo abstraktu: 839
Kategorie: Maligní lymfomy a leukémie

Leukemias - Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis

Prognostic Impact of Peripheral Blood Involvement during Early Time Points of Childhood ALL Treatment

Autoři: MUDr. Jana Volejníková; MUDr. Eva Froňková, Ph.D.; MUDr. Ester Mejstříková, Ph.D.; Kateřina Mužíková; Bc. Leona Rezková Řezníčková; doc.MUDr. Dagmar Pospíšilová, Ph.D.; prof. MUDr. Jaroslav Štěrba, CSc.; Jabali Yahia; MUDr. Daniela Procházková; Blazek Bohumir; MUDr. Jiří Hák; Cerna Zdenka; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.
Číslo abstraktu: 1489
Kategorie: Maligní lymfomy a leukémie

MRD Monitoring of Childhood ALL Using Hierarchical Clustering and Support Vector Machine Learning of Complex Multi-Parameter Flow Cytometry Data

Autoři: Mgr. Karel Fišer, Ph.D.; Tomas Sieger; Angela Schumich; Julie Irving; Prof. MD Michael Dworzak; Josef Vormoor
Číslo abstraktu: 1508
Kategorie: Maligní lymfomy a leukémie

Identification of Gene Expression Signatures Accurately Predicting Cytogenetic Subtypes in Pediatric Acute Myeloid Leukemia

Autoři: V. Balgobind Brian; MD Marry M. van den Heuvel-Eibrink, PhD; X. Menezes Renee; MD Dirk Reinhardt, PhD; MD Iris H.I.M. Hollink, PhD; Susan T.C.J.M. Arentsen-Peters; R. van Wering Elisabeth; MD Gertjan (J.L.) Kaspers, PhD; Jacqueline Cloos, Ph.D.; MD Eveline S.J.M. de Bont, PhD; MD Andre Baruchel, PhD; Jean-Michel Cayuela, PhD.
Číslo abstraktu: 1509
Kategorie: Maligní lymfomy a leukémie

Distribution and Outcome According to Cytogenetics in 502 Paediatric AML Patients Treated in Study AML-BFM 98

Autoři: MD Christine von Neuhoff; Jutta Bradtke; Martin Zimmermann, Ph.D.; MD Jean-Pierre Bourquin, PhD; MD David Betts; prof. MUDr. Jan Starý, DrSc.; Doc.RNDr. Zuzana Zemanová, CSc.; Prof. MD Michael Dworzak; MD Dirk Reinhardt, PhD; MD Ursula Creutzig, PhD
Číslo abstraktu: 1510
Kategorie: Maligní lymfomy a leukémie

Prognosis of ProB ALL in Children

Autoři: Prof. MUDr. Ondřej Hrušák, Ph.D.; MUDr. Ester Mejstříková, Ph.D.; MUDr. Kateřina Zdráhalová; Mgr. Karolina Škvárová Kramarzová, Ph.D.; Mgr. Martin Kováč; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Starý, DrSc.
Číslo abstraktu: 2512
Kategorie: Maligní lymfomy a leukémie

Overexpression of the Differentiation-Defective G-CSF Receptor Isoform IV Is Associated with a High Incidence of Relapses in Childhood Acute Myeloid Leukemia Treated with G-CSF

Autoři: Ehlers Stephanie; Herbst Christin; Martin Zimmermann, Ph.D.; Scharn Nicole; Germeshausen Manuela; Claudia Langebrake; Thomas Lehrnbecher; Jochen Harbott; prof. MUDr. Jan Starý, DrSc.; Prof. MD Michael Dworzak; MD Ursula Creutzig, PhD; MD Dirk Reinhardt, PhD
Číslo abstraktu: 2528
Kategorie: Maligní lymfomy a leukémie

MRD Monitoring Reveals a Specific Biology of BCR/ABL-Positive ALL

Autoři: MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Bc. Leona Rezková Řezníčková; MUDr. Eva Froňková, Ph.D.; Kateřina Krejčíková; Kateřina Mužíková; Claus Meyer; Rolf Marschalek; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 2529
Kategorie: Maligní lymfomy a leukémie

Flow Cytometric Detection of BCR-ABL Fusion Proteins in Leukemia Patients Via An Immunobead Assay

Autoři: Weerkamp Floor; E. Dekking; Vincent H.J. Van der Velden, PhD; MD Sebastian Böttcher; Prof. Dr. Nancy Boeckx; R. van Wering Elisabeth; Montero Juan Flores; Lucio Paulo; Sedek Lukasz; prof. MUDr. Tomáš Kalina, Ph.D.; Macintyre Elizabeth; Frank J.T. Staal ; MD Jacques J.M. van Dongen, PhD
Číslo abstraktu: 2533
Kategorie: Maligní lymfomy a leukémie

Lymphoma: Chemotherapy and Clinical Trials

Eight Cycles of BEACOPP Escalated Compared with 4 Cycles of BEACOPP Escalated Followed by 4 Cycles of BEACOPP Baseline with Our without Radiotherapy in Patients in Advanced Stage Hodgkin Lymphoma (HL): Final Analysis of the Randomised HD12 Trial of t

Autoři: MD Volker Diehl; Heinz Haverkamp; Rolf Peter Mueller; Eich Hans Theodor; Hans Konrad Mueller-Hermelink; Cerny Thomas; MUDr. Jana Marková; Prof.MD Anthony D. Ho, PhD, FRCP; Kanz Lothar; MD Richard Greil, Ph.D.; MD Wolfgang Hiddemann; Prof. MD Andreas Engert
Číslo abstraktu: 1558
Kategorie: Maligní lymfomy a leukémie

Molecular Pharmacology, Drug Resistance

Bcr-Abl-Independent Activation of Src Kinases Associated with Development of Dasatinib Resistance in a CML Patient

Autoři: Mgr. Jitka Veselovská, Ph.D.; Mgr. Renata Mojzíková (Solná), Ph.D.; Prof. RNDr. Mgr. Marie Jarošová, CSc.; prof. MUDr. Edgar Faber, CSc.; Mgr. Helena Urbánková, Ph.D.; RNDr. Milena Holzerová, Ph.D.; Mgr. Jana Balcárková, Ph.D.; prof. MUDr. Karel Indrák, DrSc.; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 1624
Kategorie: Maligní lymfomy a leukémie

Acquired Resistance to Tumor Necrosis Factor-Related Apoptosis- Inducing Ligand (TRAIL): Histone Deacetylase Inhibitors Resensitize TRAIL-Resistant Jurkat Acute Lymphocytic Leukemia Cells

Autoři: prof. MUDr. Pavel Klener, DrSc.; MUDr. Jan Molinský; Mgr. Tereza Šimonová; Prof. MUDr. Emanuel Nečas, DrSc.; RNDr. Ladislav Anděra, CSc.; Doc.MUDr. Jan Živný, Ph.D.
Číslo abstraktu: 5032
Kategorie: Maligní lymfomy a leukémie

NTAL Potentiates Glucocorticosteroid-Induced Apoptosis in T-ALL – in Vivo Observations and Experimental Model

Autoři: MUDr. Karel Švojgr, Ph.D.; Mgr. Tatiana Burjanivová, Ph.D.; Mgr. Martina Vášková; prof. MUDr. Tomáš Kalina, Ph.D.; Mgr. Tomáš Brdička; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 5043
Kategorie: Ostatní

Myelodysplastic Syndromes

European Leukemianet (ELN) Project Diagnostic Platform (WP10): Final Results of the First Study of the European Morphology Consensus Panel

Autoři: Zini Gina; Bain Barbara; Gianluigi Castoldi; José Cortez; Judit Csomor; prof. MUDr. Edgar Faber, CSc.; MD Aristoteles Giagounidis, PhD; MD Torsten Haferlach; MUDr. Petra Kačírková; Krzysztof Lewandowski; Vincenzo Liso; Estella Matutes; M.D. Marc Maynadie, Ph.D.; Prof. John Meletis, MD; Anna Porwit; M. Leticia Ribeiro, MD
Číslo abstraktu: 1645
Kategorie: Myelodysplastický syndrom

Modification of WPSS for the Time of Diagnosis Retains Its Prognostic Impact and Confirms Transfusion Dependency as An Important Parameter Affecting Survival in Early MDS Patients with Isolated Erythroid Dysplasia

Autoři: prof. MUDr. Jaroslav Čermák, CSc.; MUDr. Dana Mikulenková; MUDr. Petra Kačírková; prof. Ing. Kyra Michalová, DrSc.
Číslo abstraktu: 1654
Kategorie: Myelodysplastický syndrom

Molecular Cytogenetic Studies of Complex Karyotypes in Myelodysplastic Syndromes (MDS): Conventional Cytogenetics, FISH and Multiplex FISH (mFISH/mBAND)

Autoři: Doc.RNDr. Zuzana Zemanová, CSc.; prof. Ing. Kyra Michalová, DrSc.; RNDr. Jana Březinová, Ph.D.; RNDr. Libuše Lizcová; Mgr. Silvia Izáková; MUDr. Olga Černá; prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 5075
Kategorie: Myelodysplastický syndrom

Gene Expression Profiles of CD34+ Cells in Myelodysplastic Syndrome

Autoři: Mgr. Monika Běličková; Alzbeta Vasikova; Mgr. Eva Budinská, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 5078
Kategorie: Myelodysplastický syndrom

Can Gene Methylation, Telomere Length and Activity of Telomerase Help with Individual Risk and Treatment Strategy of MDS Patients?

Autoři: Mgr. Hana Čechová; Mgr. Soňa Včelíková (Žilovcová ); Hana Lastuvkova; Martina Skálová; Doc.RNDr. Zuzana Zemanová, CSc.; prof. Ing. Kyra Michalová, DrSc.; prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 5087
Kategorie: Myelodysplastický syndrom

Myeloma - Biology and Pathophysiology, Excluding Therapy

Proteomic Analysis of Multiple Myeloma Cells Targeted with Bortezomib

Autoři: Mgr. Jana Čumová; Mgr. Anna Potáčová, Ph.D.; Mgr. Irena Kasalová; Mgr. Ondrej Šedo; RNDr. Hana Konečná; Doc. RNDr. Zbyněk Zdráhal, Dr.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 5133
Kategorie: Mnohočetný myelom

Flow Cytometric Detection of Minimal Residual Disease in Multiple Myeloma Patients

Autoři: Mgr. Lucie Říhová, PhD.; RNDr. Ivana Burešová; prof. MUDr. Luděk Pour, Ph.D.; Prof. MUDr. Jaroslav Michálek, Ph.D.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 5141
Kategorie: Mnohočetný myelom

The Evaluation of Light Chains USING ELISA Method

Autoři: Ing. Jaroslava Vávrová, Ph.D.; RNDr. Bedřich Friedecký, Ph.D.; Prof. RNDr. Miloš Tichý, CSc.; PharmDr. Magdalena Holečková; Doc. MUDr. Vladimír Maisnar, Ph.D.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 5147
Kategorie: Mnohočetný myelom

Myeloma - Therapy, Excluding Transplantation

Bortezomib-Doxorubicin-Dexamethasone (BDD) for Reversal of Acute Light Chain Induced Renal Failure (ARF) in Multiple Myeloma (MM). Results from a Phase II Study

Autoři: Prof. MD Heinz Ludwig; prof. MUDr. Zdeněk Adam, CSc.; prof. MUDr. Roman Hájek, CSc.; MD Richard Greil, Ph.D.; M.D. Felix Keil; Dr. Niklas Zojer; Dr. Josef Thaler, Ph.D.; MD Heinz Gisslinger; Dr. Alois Lang
Číslo abstraktu: 3682
Kategorie: Mnohočetný myelom

The Reduced Intensity Cvd Regimen: A Good Option with Well Balanced Efficacy/Toxicity Ratio for Elderly Patients with Poor Status Performance

Autoři: prof. MUDr. Roman Hájek, CSc.; MUDr. Lenka Zahradová, Ph.D.; MUDr. Evžen Gregora; MUDr. Miroslava Schűtzová; MUDr. Vladimír Koza (1954 - 2012); MUDr. Petr Pavlíček; prof. MUDr. Luděk Pour, Ph.D.; Prof. MUDr. Marta Krejčí, Ph.D.; MUDr. Viera Sandecká, Ph.D.; MUDr. Andrea Křivanová, Ph.D.; MUDr. Mohammed Al Sahmani; Ing. Dana Dvořáková, CSc.; prof. MUDr. Zdeněk Adam, CSc.
Číslo abstraktu: 3699
Kategorie: Mnohočetný myelom

Myeloma Therapy: Phase III Trials

Updated Follow-up and Results of Subsequent Therapy in the Phase III VISTA Trial: Bortezomib Plus Melphalan–Prednisone Versus Melphalan–Prednisone in Newly Diagnosed Multiple Myeloma

Autoři: Prof. M.D. Jesús San Miguel, Ph.D.; MD Rudolf Schlag; K. Khuageva Nuriet; Meletios Athanasios Dimopoulos, MD; MD Ofer Shpilberg, MPH; MD Martin (H.) Kropff; Prof.MUDr. Ivan Špička, PhD; MD Maria Teresa Petrucci; MD Antonio P. Palumbo; MD Olga S Samoilova; Anna Dmoszynska; Prof. Kudrat M Abdulkadyrov; Schots Rik; Bin Jiang; MD Maria-Victoria Mateos, PhD
Číslo abstraktu: 650
Kategorie: Mnohočetný myelom

Myeloproliferative Disorders

JAK2 Mutation and Additional Thrombophilic Markers Predispose to Thrombosis in Myeloproliferative Diseases with Thrombocythemia

Autoři: prof. MUDr. Miroslav Penka, CSc.; MUDr. Jiří Schwarz, CSc.; prof. MUDr. Michael Doubek, Ph.D.; Doc. MUDr. Petr Dulíček, Ph.D.; prof. MUDr. Karel Indrák, DrSc.; MUDr. Yvona Brychtová, Ph.D.; MUDr. Antonín Hluší, Ph.D.; MUDr. Jarmila Kissová; prof. MUDr. Jiří Mayer, CSc.; RNDr. Tomáš Pavlík, Ph.D.
Číslo abstraktu: 5257
Kategorie: Ostatní

Final Results of the ANAHYDRET-Study: Non-Inferiority of Anagrelide Compared to Hydroxyurea in Newly Diagnosed WHO-Essential Thrombocythemia Patients

Autoři: MD Heinz Gisslinger; Mirjana Gotic; Jerzy Holowiecki; prof. MUDr. Miroslav Penka, CSc.; Juergen Thiele; Hans Michael Kvasnicka ; Robert Kralovics, PhD; Petro E. Petrides
Číslo abstraktu: 661
Kategorie: Ostatní

Non-Hodgkin's Lymphoma - Biology, Excluding Therapy

Mantle Cell Lymphoma International Prognostic Score Is Valid and Confirmed in Unselected Cohort of Patients Treated in Rituximab Era

Autoři: MUDr. David Šálek, Ph.D.; MUDr. Ingrid Vášová; MUDr. Robert Pytlík, Ph.D.; MUDr. David Belada, Ph.D.; doc. MUDr. Tomáš Papajík, CSc.; MUDr. Kateřina Kubáčková; MUDr. Jan Pirnos; Doc. MUDr. Ludmila Boudová, Ph.D.; prof. MUDr. Roman Kodet, CSc.; MUDr. Petra Obrtlíková, Ph.D.; Mgr. Hana Krejčová; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 3745
Kategorie: Maligní lymfomy a leukémie

Oncogenes and Tumor Suppressors

EVI1 Overexpression in Pediatric Acute Myeloid Leukemia Associated with Unfavorable Subtypes

Autoři: V. Balgobind Brian; Lugthart Sanne; MD Iris H.I.M. Hollink, PhD; Susan T.C.J.M. Arentsen-Peters; R. van Wering Elisabeth; MD Sibold S.N. de Graaf , PhD; MD Dirk Reinhardt, PhD; MD Gertjan (J.L.) Kaspers, PhD; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; Martin Zimmermann, Ph.D.; Dr. Ruud H. Delwel, Ph.D.; Prof. MD Rob Pieters, PhD; MD Christian Michel Zwaan, PhD
Číslo abstraktu: 1802
Kategorie: Maligní lymfomy a leukémie

Delta Ex6, the Novel Transactivation-Defective Splicing Variant of p53 Gene, Is Differentially Expressed in Patients with Chronic Lymphocytic Leukemia and Confers Accented Proliferative Phenotype in Vitro

Autoři: MUDr. Soňa Peková, Ph.D.; RNDr. Radek Čmejla, Ph.D.; doc. MUDr. Tomáš Kozák, Ph.D., MBA; MUDr. Lukáš Smolej, Ph.D.; MUDr. Martin Špaček; Doc.MUDr. Miroslav Průcha, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.
Číslo abstraktu: 3795
Kategorie: Maligní lymfomy a leukémie