Hypoxiradiotherapy I, the experimental study

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Klin Onkol 1990; 3(4): 116-118.

Summary:

A review of literature and the results of studies are presented concerning the radioprotective effects of aerogenic hypoxia. In experiments on animals the phenomenon of tissue adaptation to the radioprotective action of hypoxia is documented, which is reflected in a dependence of its protective effect on the period of stay of animals in hypoxia before irradiation. Data are presented on a differentiated protection by means of hypoxia of normal tissues and an experimental tumour where the regression of Walker carcinoma after the irradiation of animals in hypoxia (8% 02) was the same as that after irradiation in air, while the other tissues were protected by hypoxia.