Preinvasive Lesions in Gynecology – Vulva


Klin Onkol 2013; 26(Suppl): 44-46. DOI: 10.14735/amko2013S44.


For preinvasive lesions of vulva, a common term VIN – vulval intraepithelial neoplasia is used. VIN is a histological diagnosis based on abnormal squamous epithelial proliferation. There are two types of VIN apart from their association with human papillomavirus (HPV). Undifferentiated (usual) vulval intraepithelial neoplasia is commonly associated with carcinogenic genotypes of HVP, whereas differentiated vulval intraepithelial neoplasia is not associated with high-risk genotypes of HPV. The article presents an overview of VIN occurence and epidemiology, its classification system and diagnostics. In conclusion, VIN therapeutical possibilities are presented. It can be treated with surgical therapy (local excision, partial vulvectomy, vulvectomy, laser vaporization) or medical therapy (imiquimod).

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