Klin Onkol 2000; 13(Speciál2 2000): 58-59.
Summary: Advanced ovarian cancer is a serious therapeutical problem. This paper shows on example of three patients the importance of in vitro drug resistance assay for explanation of disease outcome. The first patient was diagnosed in stage III. After suboptimal surgery she was treated with combination of cyclophosphamide, doxorubicin and cisplatin with very good response (in vitro drug sensitive). The second patient also in stage III progressed rapidly on both carboplatin alone or in combination with paclitaxel (in vitro drug resistant). The third patient was suffering from relaps of ovarian cancer. She failured on 2nd and 3rd line of chemotherapy, so she was treated according to results of in vitro chemosensitivity assay with transient response. Patient outcomes are discussed in correlation with in vitro drug sensitivity asssay.
