Klin Onkol 2000; 13(Speciál2 2000): 10-17.
Summary: This paper deals with three proteins known to associate with atypical multidrug resistance (atMDR) of tumor cells. Multidrug resistance protein (MRP) works as an ATP-dependent membrane „pump“ and belongs, together with P-glycoprotein (Pgp), to a superfamily of ABC-transport proteins. Lung resistance protein (LRP) is a major component of organelles called „vaults“. Vaults are able to transport toxic agents from the nuclei of neoplastic cells to lysosoms. Additionaly increased activity of glutathion-S-transferase enzyme (GST-p) followed by increased concentration of reduced form of glutathion (GSH) protects tumor cells from oxidative damage. Basic characteristics of MRP, LRP and GST-p are given including their structures, functions and expressions in normal/malignant human tissues. Studies focused on the significance of mentioned proteins for clinical MDR are reported as well.
