Summary: Randomized clinical study represents to date the most effective measure for clinical research aimed to search for optimal therapies, but it should not remain its only goal. It is most important that the results of a controlled clinical study can be implemented in routine practice and repeated in non-selected groups of patients. In the Czech Republic the possibility exists to compare the impact of widely accepted protocols from clinical studies in nationwide population cancer registry managed since 1977. The parameters of the National Cancer Registry include also the data on diagnosis and treatment in each reported case. The database can be analyses by an unique software for viewing oncological data (SVOD) developed in the Center of Biostatistics and Analyses of the Masaryk University in Brno. The differences between the results form clinical studies and actual practice as well as variations in treatment results between different hospitals can be envisaged also as equity issue. In the article, there are demonstrated six examples of results achieved in population registry from routine practice which are concordant with conclusions from controlled clinica studis and their meta-analyses. The examples include results of adjuvant chemotherapy in stage II breast cancer and stage III colorectal cancer, preoperative radiotherapy in stage III rectal cancer, adjuvant chmotherapy in stage III malignant melanoma, comparison on various therapies in hepatocellular carcinoma and chemotherapy in stage III-IV soft-tisssue sarcomas.