Klin Onkol 2006; 19(4): 234-242.
Summary
The purpose of the retrospective study was to determine whether concurrent chemoradiotherapy is better than radiotherapy alone in respect of treatment results and side-effects of patients with advanced cervical carcinoma. The total number of patients included in the study was 193. Patients were divided into two groups. 93 patients were treaded with adjuvant radiotherapy or radiotherapy alone and 100 patients were treaded with radical or adjuvant concurrent chemoradiotherapy. DFS (Desease-Free Survival) and OS (Overall Survival) were compared between the two patient groups by the Kaplan-Meier method at 5% of significance level. In general, there was no significant diference between DFS and OS of patients in the two tested groups. However, when only the patients with positive lympf nodes were analysed, then chemoradiotherapy has proved to be more efficient therapy in terms of DFS duration (Log-Rank test, p=0,023<0,05) and OS duration (Log-Rang test, p=0,012<0,05). 74,2% (67,0% resp.) patients treated by chemoradiation and 62,7% (31,3% resp.) patients treated by radiation alone were without relaps after 2 (5 years resp.). 81,7% (73,8% resp.) patients treated by chemoradiation and 78,9% (35,4% resp.) patients treated by radiation alone were alive after 2 (5 years resp.). With the exception of acute gastrointestinal and early urinary tract toxicity, the general toxicity in concurrent chemoradiotherapy was significantly higher when evaluated by Chi-square test.
