Lymphatic mapping and sentinel lymph node biopsy in patients with endometrial cancer


Klin Onkol 2007; 20(2): 199-204.

The endometrial carcinoma remains the most frequent gynecological malignity. The incidence is 30:100 000 with an increasing tendency. The main therapeutic modality remains radical surgery, including hysterectomy, bilateral adnexectomy, peritoneal wash, pelvic lymphadenectomy and paraaortal lymphadenectomy in cases of high-risk prognostic factors positivity. In agreement with the trend of decreasing oncological surgery radicality, sentinel node detection of endometrial cancer appears to be a promising method with the potential of decreasing surgery radicality and staging clarification. First experiences imply that utilization of hysteroscopic application of radiocoloid respects the anatomical consequences and natural lymphatic drainage of endometrium best. Combination of pre-operative
lymphoscintigraphy and intra-operative detection using handheld gamma probe can be beneficial for sentinel lymph node identification in early endometrial cancer.