Klin Onkol 2007; 20(2): 220-223.

Background: N-terminal propeptide of type I procollagen (P1NP) is recommended for monitoring of the bone formation process.
Subjects, Methods. This study involved 183 breast carcinoma patients. In part of this group the bone scintigraphy was compared with serum P1NP levels (Elecsys method, Roche). Results. The average P1NP concentration in the group of patients with proved bone metastases (N = 118) was significantly higher in comparison with patient groups without metastases. This P1NP method displays a 46% clinical sensitivity with 90 % specificity. Conclusions. Monitoring of P1NP concentration changes can supplement bone scintigraphy
during monitoring of specific bisphosphonate treatment. A comprehensive assessment of the predictive value of serum P1NP measurement will be performed following increase of patient numbers in this study.