Klin Onkol 2008; 21(4): 169-173.
Backgrounds: Local recurrences in breast after conservative surgery are failure of primary therapy. The aim of the study was monitoring of local recurrences after conservative surgery and also relationships of local recurrences with disease free interval and survival. Materials and Methods: Between 1.12. 1998 and 30.06.2004, 143 patients with breast carcinoma were treated at Department of Surgery Atlas Hospital Zlin by conservative surgery. All patients received radiotherapy and boost in breast. Macroscopic free margins were l0 mm and reexcision were done in all patients with free margins less than 5mm. Dose of the radiotherapy whole breast and cavity were 50Gy, interval 5-6 weeks, daily 2Gy. Brachytherapy received all patients, combination of chemotherapy and hormonal therapy were 56x, only chemotherapy 31x, only hormonal therapy 31x and without adjuvant therapy 25x. Results: Median follow-up was 32 month. Tumor size according to TNM classifi cation: TIS 10, pT1a 1x, pTb 28x, pTc 55x, pT2 44x, pT3 5x. Stage: 0 1x, I 58x, IIA 56x, IIB 24x, IIIA 4x. Local recurrences in breast were 5x, (3, 49%), distant metastases 6x, (4, 1%) and 3x (2, 09%) appeared distant metastases and death at breast carcinoma without local recurrence. Only in one patient local recurrence were followed by distant
metastases and death. Interval from local recurrence and death was 12 month. Size of the original tumor with local recurrences was from 10mm to 45 mm. Interval from the time of initial treatment to local recurrences was from12 to 42 month. Surgical treatment of local recurrences included mastectomy 4x and conservative surgery 1x. Conclusion: Number of local recurrences is in correspondence with international guideline and results of modern multimodal therapy.
