Importance of Prognostic Factors in a Choice of Optimal Therapeutical Strategy in Patients with Non-Hodgkin s Lymphomas


Klin Onkol 2001; 14(3): 85-89.

Summary: Non-Hodgkin´s lymphomas constitute a heterogenous group of malignancies. Variability of course not only among different histological entities but also within each of them belong to their characteristic features. Evaluation of individual patient´s risk is necessary for optimal choice of therapy and its intensity. For this purpose we have single prognostic factors or prognostic indexes. Age, perfomance status, disease stage, involvement of extranodal sites and lactate-dehydrogenase value are considered as basic prognostic factors. These factors create the Intemational prognostic index (lPI) which can be used as standard prognostic indicator for all types of non- Hodgkin´s lymphomas. Some new prognostic parameters seem to be important - especialy B2-microglobulin, markers of proliferating activity of neoplastic cells and genetic changes.

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