Klin Onkol 2001; 14(3): 102-105.
Summary: Backgrounds: Non-Hodgkin´s lymphomas (NHL) represent a heterogeneous group of neoplasms which are characterized by substantial difference of their course even within each histological category. Today we have very broad therapeutic potential. A choice of appropriate kind and intensity oftherapy based on individual risk decision markedly affect
not only a patienťs prognosis bul also a quality or life during therapy and after it. Design and Subjects: Importance of
selected prognostic factors serum lactate dehydrogenase (LDH), ß2-microglobuline (ß2M), serum thymidin-kinase (sTK) and International prognostic index (lPI) to the stratification of theřapeutic approach was retrospectively evaluated in the group of 123 patients with different histological subtypes of NHL. Data were statistically analyzed by Pearson's correlation test, matched T -test and chi-square test. Methods aod results: Significant correlation between ß2M, s-TK values, IPI categories and response to therapy was confirmed. ß2M≥3,0 mg/l in the group of patients withIPI 2 clearly differentiated high-risk individuals with low number of therapeutic responses. LDH and ß2M index did not provide any new substantial information in comparison withIPI and ß2M. An applicability of IPI in a group of low-grade NHL was also confirmed bul relatively small number of patients were classified as high-risk according to IPI. Conclusions: Authors confirmed requirement of prognostic stratification of NHL patients in connection with type and intensity of therapy,IPI, ß2M and sTK values can be considered as basic, easy available and universal prognostic factors
