COMPARISON OF GALACTOMANNAN DETECTED IN SERUM/ BRONCHOALVEOLAR LAVAGE FLUID AND TYPE OF ABNORMALITY ON PULMONARY HIGH RESOLUTION COMPUTER TOMOGRAPHY IN PATIENTS WITH PULMONARY INVASIVE ASPERGILLOSIS

Konference: 2014 19th Congress of the European Hematology Association - účast ČR

Kategorie: infekce

Téma: Infectious diseases, supportive care (Poster)

Číslo abstraktu: P1192

Autoři: MUDr. Barbora Weinbergerová (Wágnerová); Prof. MUDr. Zdeněk Ráčil, Ph.D.; Mgr. Denisa Malúšková; RNDr. Jan Mužík, Ph.D.; Mgr. Iva Kocmanová; MUDr. Luboš Drgoňa, CSc.; MUDr. Michal Kouba; MUDr. Mariana Hričinová; MUDr. Tomáš Guman, Ph.D.; Juliana Gabzdilová; MUDr. Jan Haber, CSc.; RNDr. Kristýna Forsterová; MUDr. Eva Bojtárová; Barbora Žiaková; MD Jan Novák, Ph.D.; MUDr. Vanda Chrenková; prof. MUDr. Petr Sedláček, CSc.; Doc. MUDr. Samuel Vokurka, Ph.D.; MUDr. Peter Múdry, Ph.D.; MUDr. Barbara Tkačíková; MUDr. Alžběta Zavřelová; Doc. MUDr. Pavel Žák, Ph.D.; Alen Ostojic; Radovan Vrhovac; MUDr. Daniela Šejnová; Viktor Zatezalo; Njetocka Gredelj; MUDr. Naďa Mallátová; MUDr. Pavel Timr; MUDr. Julia Horáková; MUDr. Alica Chocholová; MUDr. Milan Navrátil; prof. MUDr. Roman Hájek, CSc.; Mgr. Monika Rolencová; prof. MUDr. Jiří Mayer, CSc.; doc. MUDr. Petr Cetkovský, Ph.D.; Doc. RNDr. Ladislav Dušek, Ph.D.

ABSSUB-5549

Background: Up to now there have been missing data in the literature concerning relationship of galactomannan (GM) detected in bronchoalveolar lavage (BAL) fluid and type of abnormality on pulmonary high resolution computer tomography (HRCT) in patients (pts.) with pulmonary invasive aspergillosis (IPA).

Aims: To evaluate relationship between sensitivity of GM detected in BAL fluid and serum (S-GM) and type of abnormality on pulmonary HRCT in pts. with IPA.

Methods: We retrospectively analyzed mentioned relationship in pts. with probable and proven IPA entered in …Fungal InfectioN Database (FIND)“ aspergillus between 2001 and 2012.

Results: In total there were 143 IPA cases with GM detected in BAL fluid analyzed at the time of diagnosis. Overall positivity of GM in BAL fluid (1 sample ≥ 0.5 IP) was 86% in these pts. Sensitivity of GM in BAL fluid was significantly higher in pts. with pulmonary nodules than infiltrates on HRCT (89.7% vs. 76.2%; p= 0.043). There was no statistically significant relationship between value of GM in BAL fluid and type of HRCT finding (p= 0.690). S-GM was detected in 312 pts. with IPA. Overall positivity of S-GM (2 consecutive samples ≥ 0.5 IP) was 68.6% in these pts. Similarly to GM in BAL fluid there were proved statistically significant difference in sensitivity of S-GM in pts. with nodules and infiltrates on HRCT (78.0% vs. 62.0%; p= 0.004). There was also found no statistically significant relationship between value of S-GM and type of HRCT finding (p= 0.321).

Summary/Conclusion: Our study proved higher sensitivity of both GM in BAL fluid and S-GM in IPA pts. with more specific findings – nodules compare to non specific findings – infiltrates on HRCT.

Keywords: Invasive aspergillosis

Datum přednesení příspěvku: 14. 6. 2014