Konference: 2007 ECLU Congress ESMO - účast ČR
Téma: Basic science and bench to bedside
Číslo abstraktu: 006P
function in cancer can be characterized similarly as in atherosclerosis as a generalised endothelial dysfunction and if the signs of endothelial activation are present already in patients with non-metastatic breast cancer.
Methods: We examined soluble(s) P-selectin, E-selectin, ICAM-1 and VEGF,coagulation parameters and flow-mediated vasodilation and their relation to TNM classification, size of the tumor, its grade, expression of estrogen and progesterone and Her/neu receptors and the clinical outcome in 57 patients with breast cancer.
Preliminary results: plasma levels of sE-selectin, but not sP-selectin, sICAM-1 and VEGF correlated with the size of the tumour (median levels 43.2 vs. 77.4 vs. 95.5 ng/ml in T2, T3 and T4 tumours, respectively, P < 0.05).sE-selectin correlated with sICAM-1 (r = 0.553, P < 0.001) and sP-selectin correlated with VEGF (r = 0.364, P < 0.005). In conclusion, increase of plasma levels of sE-selectin could have been demonstrated not only in patients with metastatic breast cancer, but also in patients with large nonmetastatic tumour. Further studies should delineate if the increase of sE-selectin is also accompanied by other signs of endothelial dysfunction, e.g. impaired flow-mediated vasodilation.
Supported by the grant of IGA of the Ministry of Health of the Czech Republic No.9020-3.
Datum přednesení příspěvku: 5. 7. 2007