PATIENTS AFTER GRAFTING AND SOLID TUMOURS - TREATMENT

Konference: 2006 31st Congress ESMO - účast ČR

Kategorie: Onkologická rizika a prevence

Téma: Prevention and screening

Číslo abstraktu: 962P

Autoři: MUDr. Dagmar Brančíková, Ph.D.; MUDr. Vladimír Spurný, CSc.; Miroslava Sláviková; MUDr. Zdeněk Mechl, CSc.; MUDr. Otakar Bednařík, CSc.; MUDr. Renata Červená, Ph.D.; MUDr. Marek Slávik

Patients after organ transplantation have high probability of second cancer occurence. The incidence of malignant diseases is increasing with longer survival of recipients and the admission of older patients for transplantation programs and immunosupressive treatment .

Material: between 2000-2004, 26 patients, with median age 61 years (32-70 ) were treated in our hospital.
15 pts waere after heart transplantation,
11 pts were ater kidney transplantation
Fifty percent of disease was diagnosed in the stage IV.
.
Time from transplantation to bursting of the new tumorr: 2-13 years, median 7 years.
Charasteristrics of the second tumors:
Skin cancer - 10 pts. - 5- SCC, 2- BCC, 1- SCC+BCC, melanoma malignum
sebaceous adenoCa - 2 pts. high stage
Colorectal cancer - 6 pts. - adenoCa (4x high grade, 2x low grade) 2pts with stage .III and 2 with stage IV
Breast cancer - 6 pts. (1male and 5 female)- ductal a lobular Ca high grade,2pts with stage IV and 3 pts st.III
other tumours - 4 pac.(tumour of the prostate, stomach, Grawitz , primum ignotum)
- (3 pts. high stage in the time of diagnosis )
Therapy:
skin tumours : surgery + RT
other tumours: surgery - chemotherapy - radiotherapy
12 pts chemotherapy only
Colorectal cancer chemotherapy
Breast cancer chemotherapy

Toxicity of chemotherapy:
- leucopenia G4 in 10 pts. (febril. neutropenia 3 case)
- gastrointestinal G4 in 4 pts
- hepatorenal insuficience gr 3/4 with 2 patients
The toxicity of chemotherapy is very relevant and progression of disease

Conclusions:
The patients after trasplantation are in high risk for incidence of malignancy.. These patients needs a very more precise follow-up, as 26 pacients out of 242.. with secondary malignancy represent a very serious number.

Datum přednesení příspěvku: 29. 6. 2006