Konference: 2009 5. sympózium a workshop molekulární patologie a histo-cyto-chemie
Nádorová biologie/imunologie/genetika a buněčná terapie
Téma: The role of the pathologist in the indication of the cancer treatment
Číslo abstraktu: 008
Autoři: prof. MUDr. Bohuslav Melichar, Ph.D.
In the last few years, targeted therapy has
become an integral part of the armamentarium of medical oncology.
Targeted agents have been introduced into the treatment of the most
common malignant tumors, including breast, colorectal and non-small
cell lung carcinoma. The advent of targeted therapy has also
changed the course of tumors that were hitherto resistant to any
systemic agents, e.g. renal cell carcinoma and gastrointestinal
stromal tumors. The term targeted therapy implies a precise
knowledge of the target but with some targeted agents the expanding
knowledge on tumor biology has so far failed to translate into
defining a predictive factor. On the other hand, evidence is
emerging that the host immune response may play a crucial role in
determining the response to some targeted agents, specifically
monoclonal antibodies. Thus, algorithms for the prediction of
response to targeted treatment may include not only molecular
targets expressed by the tumor cell but also parameters determining
the host immune response.
Datum přednesení příspěvku: 24. 4. 2009