Kategorie: Onkologická diagnostika
Téma: Keynote lectures of invited speakers
Číslo abstraktu: 012
Autoři: RNDr. Jiří Hejnar, CSc.
Another example of newly emerging retroviral infections to be discussed is the XMRV, a human retrovirus related to the xenotropic murine leukemia virus. In several but not all recent studies, XMRV was documented to be present in patients with certain type of prostatic carcinoma and even in cohorts of patients with chronic fatigue syndrome (CFS). It remains to be understood whether XMRV plays a role in the patogenesis of prostatic carcinoma and CFS. Similarly, HMTV, retrovirus related to the mouse mammary tumor virus is associated with autoimmune primary biliary cirrhosis and certain types of mammary carcinoma.
A possible source of a new zoonosis might be the xenotransplantation of porcine organs or tissues. Porcine endogenous retroviruses (PERV), particularly recombinant PERV-A-C, infect human cells in vitro and impose a potential rise on therapeutic xenotransplantation. Although PERV transmission to the grafted humans or experimental baboons was not detected so far in vivo, the use of genetically modified GALKO pigs will require new prospective studies. Thanks to the integration polymorphism, some PERV copies can be eliminated during the breeding of donor pigs and, therefore, the identification of highly expressed and recombinogenic PERV-A and PERV-C copies is urgently needed.
Last but not least, infectious retroviruses might emanate even from human endogenous retroviruses (HERV) integrated in the human genome, which form 8% of our DNA. This is the case of multiple sclerosis-related virus (MSRV) similar to HERV type W. MSRV is considered as a proinflammatory agent in several human neurological disorders like optic neuritis, multiple sclerosis, and CFS. The diagnostic and prognostic value of XMRV, HMTV, and MSRV detection in blood and cerebrospinal fluid will be discussed.
This abstract refers to the research supported by the grant No. 301/09/2031 awarded by the Czech Science Foundation and Framework Program 6 project XENOME by the European Committee.
Datum přednesení příspěvku: 23. 4. 2010