Konference: 2007 3. ročník Dny diagnostické, prediktivní a experimentální onkologie
Kategorie: Onkologická diagnostika
Téma: 10. Karcinogeneze a toxikologie protinádorových léčiv
Číslo abstraktu: 047
Autoři: doc .RNDr Erika Halašová, Ph.D.; RNDr. Tatiana Matáková, Ph.D.; Ľ. Mušák; J. Valachová; V. Poláková; MUDr. Jana Slyšková; I. Poliaček; Mgr. Michaela Šváchová; E. Bukovská
The aim of this study was to conduct a bio monitoring study in
welders by employing chromosomal aberration in peripheral blood
lymphocytes as a marker of genotoxic effect in relation to genetic
polymorphisms of repair gene hOGG1 as a biomarker of individual
susceptibility to procarcinogens.
We found higher frequency of chromosomal aberrations in exposed group 1.96% than in control group 1.55%. The difference was not significant. In chromatide type aberrations, there was a significant difference (P=0.050) between exposed smokers (1.21%) and non-smokers (0.63%).
Significantly higher chromosome type aberrations (CSA) were detected in individuals with homozygous variant and heterozy¬gous polymorphisms (1.27%) as compared to those with wild-type genotype (0.85%) in hOGG1gene.
We did not find any correlation between chromium level in the blood and chromosomal aberrations.
Key words: chromium, chromosomal aberration, gene polymorphism, hOGG1.
We found higher frequency of chromosomal aberrations in exposed group 1.96% than in control group 1.55%. The difference was not significant. In chromatide type aberrations, there was a significant difference (P=0.050) between exposed smokers (1.21%) and non-smokers (0.63%).
Significantly higher chromosome type aberrations (CSA) were detected in individuals with homozygous variant and heterozy¬gous polymorphisms (1.27%) as compared to those with wild-type genotype (0.85%) in hOGG1gene.
We did not find any correlation between chromium level in the blood and chromosomal aberrations.
Key words: chromium, chromosomal aberration, gene polymorphism, hOGG1.
Datum přednesení příspěvku: 30. 11. 2007
