Lanreotide autogel/depot (LAN) treatment for carcinoid syndrome (CS) symptoms: Patient-reported outcomes (PROs) from the SYMNET study.

Konference: 2014 50th ASCO Annual Meeting - účast ČR

Kategorie: Gastrointestinální nádory

Téma: Postery

Číslo abstraktu: 4111^

Autoři: Prof. M.D. Philippe B. Ruszniewski; Prof. M.D. Martyn E. Caplin, FRCP; M.D. Juan W. Valle; Catherine Lombard-Bohas; Graeme John Poston; M.D. Petros Perros, BSc, MBBS, FRCP; Doc. MUDr. Luboš Holubec (jr.), Ph.D., MBA; Prof. M.D. Gianfranco Delle Fave; Denis Michel Smith; Patricia Nicolli; Pascal Maisonobe; Philippe Atlan

Abstract:

Background: Somatostatin analogs can provide CS symptom relief, but associated PROs in clinical practice, in particular patient (pt) treatment satisfaction, are less clear.

Methods: SymNET was a large multinational observational study of PRO after >3 months’ LAN for CS-related diarrhea (NCT01234168). At a routine clinic visit (CV), 273 pts reported their satisfaction with diarrhea control (primary endpoint) on a 5-point Likert scale. Secondary endpoints included health-related quality of life (HRQoL) assessed with EORTC QLQ-C30 and G.I.NET 21 questionnaires completed by pts. HRQoL scores were transformed for some items/scales so that all had a range 0–100. Summary statistics were derived from evaluable data (enrolled population).

Results: 58% (157/273) of pts were >60 yrs, 66% (176/267) had small-bowel primary tumors, and 80% (217/271) had liver metastases. At the CV, median LAN treatment duration was 11 months and 76% (203/268) [95% CI: 70–81%] were satisfied with diarrhea control (primary endpoint). QLQ-C30: problematic symptoms were fatigue, insomnia, diarrhea and, to a lesser extent, pain; in contrast, the majority of pts had no problems with other symptoms, levels of functioning were high, and global QoL only slightly lower (Table). G.I.NET 21: problematic symptoms were disease-related worries, social function, and muscle/bone pain and, to a lesser extent, gastrointestinal and endocrine symptoms; the majority of pts had no problems with other symptoms, including treatment-related effects.

Conclusions: High levels of pt satisfaction with LAN for CS-related diarrhea were generally accompanied by high levels of HRQoL functioning. These data show HRQoL levels that are currently attained in a real-world setting and may help guide future efforts in CS management. Clinical trial information: NCT01234168.

Functioning scales (higher score=better QoL)	Median score
Physical	85
Role; cognitive; social	83
Emotional	75
Global QoL	67
General symptoms scale (lower score=better symptoms)
Nausea and vomiting	0
Pain	17
Fatigue	33
Specific symptoms scale (lower score = better symptoms)
Dyspnea; appetite loss; constipation; financial difficulties	0
Insomnia; diarrhea	33