Konference: 2006 31st Congress ESMO - účast ČR
Kategorie: Gastrointestinální nádory
Téma: Upper gastrointestinal tumors
Číslo abstraktu: 1123P
factors: N-stage, performance status (PS), localization of stenosis, grade of dysphagia, relative pre-treatment weight loss, pathological complete response (pCR), pretreatment serum levels of albumin, prealbumin, leptin, soluble leptin receptor (SLR) and tumour necrosis factor alpha (TNF-a). Median survival 20.0 months and 3-year survival of 32% was determined. Treatment with CF or CPF regimens did not differ significantly (p=0.512). Significant factors positively influencing survival in univariate analysis were: PS (0 vs. 1-2, p=0.012), grade of dysphagia (mild vs. serious, p=0.001), TNF-a level (lower vs. higher, p=0.028), pCR (yes vs. not, p=0.036). Other variables mentioned above were included to multivariate analysis due to trend in univariate one (p<0.2). Two independent factors influencing survival were found out in multivariate analysis: grade of dysphagia (mild vs. serious, p=0.017) and SLR (lower vs. higher, p=0.049). PS (0 vs. 1-2) had borderline significance of p=0.062.
Conclusions: Pre-treatment serum level of SLR and grade of dysphagia were found out to be independent survival prognostic factors in this study of multimodal treatment of oesophageal cancer. Values of leptin, SLR and TNF-a need further prospective follow-up.
Supported by grant IGA MZ CR 7530-3.
Datum přednesení příspěvku: 29. 6. 2006